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FAST-02: Results from the second in-human prospective evaluation of single-fraction proton FLASH for symptomatic thoracic bone metastases.

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Title: FAST-02: Results from the second in-human prospective evaluation of single-fraction proton FLASH for symptomatic thoracic bone metastases.
Authors: Daugherty EC; Department of Radiation Oncology, University of Cincinnati, Cincinnati, OH, USA., Zhang Y; Department of Radiation Oncology, University of Cincinnati, Cincinnati, OH, USA; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA., Xiao Z; Department of Radiation Oncology, University of Cincinnati, Cincinnati, OH, USA; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA., Backus L; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA., McDonald JM; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA., Stockman B; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA., Woo J; Varian, a Siemens Healthineers Company, Palo Alto, CA, USA., McCann C; Varian, a Siemens Healthineers Company, Palo Alto, CA, USA., Russell K; Varian, a Siemens Healthineers Company, Palo Alto, CA, USA., Sharma R; Varian, a Siemens Healthineers Company, Palo Alto, CA, USA., Khuntia D; Varian, a Siemens Healthineers Company, Palo Alto, CA, USA., McGee J; Department of Radiation Oncology, OSF Healthcare, Peoria, IL, USA., Bradley JD; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA., Simone CB 2nd; Department of Radiation Oncology, New York Proton Center, New York, NY, USA., Breneman J; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA., Perentesis JP; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA., Mascia AE; Department of Radiation Oncology, University of Cincinnati, Cincinnati, OH, USA; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA. Electronic address: anthony.mascia@cchmc.org.
Source: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2026 Jun 24; Vol. 222, pp. 111671. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8407192 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0887 (Electronic) Linking ISSN: 01678140 NLM ISO Abbreviation: Radiother Oncol Subsets: MEDLINE
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  Data: FAST-02: Results from the second in-human prospective evaluation of single-fraction proton FLASH for symptomatic thoracic bone metastases.
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  Data: <searchLink fieldCode="AU" term="%22Daugherty+EC%22">Daugherty EC</searchLink>; Department of Radiation Oncology, University of Cincinnati, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Radiation Oncology, University of Cincinnati, Cincinnati, OH, USA; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Xiao+Z%22">Xiao Z</searchLink>; Department of Radiation Oncology, University of Cincinnati, Cincinnati, OH, USA; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Backus+L%22">Backus L</searchLink>; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22McDonald+JM%22">McDonald JM</searchLink>; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Stockman+B%22">Stockman B</searchLink>; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Woo+J%22">Woo J</searchLink>; Varian, a Siemens Healthineers Company, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22McCann+C%22">McCann C</searchLink>; Varian, a Siemens Healthineers Company, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Russell+K%22">Russell K</searchLink>; Varian, a Siemens Healthineers Company, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sharma+R%22">Sharma R</searchLink>; Varian, a Siemens Healthineers Company, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Khuntia+D%22">Khuntia D</searchLink>; Varian, a Siemens Healthineers Company, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22McGee+J%22">McGee J</searchLink>; Department of Radiation Oncology, OSF Healthcare, Peoria, IL, USA.<br /><searchLink fieldCode="AU" term="%22Bradley+JD%22">Bradley JD</searchLink>; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Simone+CB+2nd%22">Simone CB 2nd</searchLink>; Department of Radiation Oncology, New York Proton Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Breneman+J%22">Breneman J</searchLink>; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Perentesis+JP%22">Perentesis JP</searchLink>; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Mascia+AE%22">Mascia AE</searchLink>; Department of Radiation Oncology, University of Cincinnati, Cincinnati, OH, USA; Cancer and Blood Disease Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA. Electronic address: anthony.mascia@cchmc.org.
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  Data: <searchLink fieldCode="JN" term="%228407192%22">Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology</searchLink> [Radiother Oncol] 2026 Jun 24; Vol. 222, pp. 111671. <i>Date of Electronic Publication: </i>2026 Jun 24.
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