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Preliminary pharmacokinetic investigation of two discoidin domain receptor 2 inhibitors in murine plasma and brain using liquid chromatography-tandem mass spectrometry analysis.

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Title: Preliminary pharmacokinetic investigation of two discoidin domain receptor 2 inhibitors in murine plasma and brain using liquid chromatography-tandem mass spectrometry analysis.
Authors: Gueroue P; Department of Pharmacy, CHU Bordeaux, Pessac, F-33604, France., Burban A; CNRS, IBGC, UMR5095, University Bordeaux, Bordeaux, F-33000, France., Sharanek A; INSERM, BRIC, UMR1312, University Bordeaux, Bordeaux, F-33000, France., Bougueon G; Department of Pharmacy, CHU Bordeaux, Pessac, F-33604, France.; INSERM, ARNA laboratory, UMR1212, CNRS, ChemBioPharm, UMR5320, University Bordeaux, Bordeaux, F-33000, France., Bouchet S; Department of Medical Pharmacology, CHU Bordeaux, Bordeaux, F-33000, France.; INSERM, BPH, UMR1219, University Bordeaux, Bordeaux, F-33000, France., Ducint D; Department of Medical Pharmacology, CHU Bordeaux, Bordeaux, F-33000, France., Molimard M; Department of Medical Pharmacology, CHU Bordeaux, Bordeaux, F-33000, France.; INSERM, BPH, UMR1219, University Bordeaux, Bordeaux, F-33000, France., Djabarouti S; Department of Pharmacy, CHU Bordeaux, Pessac, F-33604, France. sarah.djabarouti@u-bordeaux.fr.; INSERM, BRIC, UMR1312, University Bordeaux, Bordeaux, F-33000, France. sarah.djabarouti@u-bordeaux.fr., Guyon J; INSERM, BRIC, UMR1312, University Bordeaux, Bordeaux, F-33000, France. joris.guyon@u-bordeaux.fr.; Department of Medical Pharmacology, CHU Bordeaux, Bordeaux, F-33000, France. joris.guyon@u-bordeaux.fr.; Department of Biochemistry, CHU Bordeaux, Bordeaux, F-33000, France. joris.guyon@u-bordeaux.fr.
Source: Scientific reports [Sci Rep] 2026 Jun 24. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Gueroue+P%22">Gueroue P</searchLink>; Department of Pharmacy, CHU Bordeaux, Pessac, F-33604, France.<br /><searchLink fieldCode="AU" term="%22Burban+A%22">Burban A</searchLink>; CNRS, IBGC, UMR5095, University Bordeaux, Bordeaux, F-33000, France.<br /><searchLink fieldCode="AU" term="%22Sharanek+A%22">Sharanek A</searchLink>; INSERM, BRIC, UMR1312, University Bordeaux, Bordeaux, F-33000, France.<br /><searchLink fieldCode="AU" term="%22Bougueon+G%22">Bougueon G</searchLink>; Department of Pharmacy, CHU Bordeaux, Pessac, F-33604, France.; INSERM, ARNA laboratory, UMR1212, CNRS, ChemBioPharm, UMR5320, University Bordeaux, Bordeaux, F-33000, France.<br /><searchLink fieldCode="AU" term="%22Bouchet+S%22">Bouchet S</searchLink>; Department of Medical Pharmacology, CHU Bordeaux, Bordeaux, F-33000, France.; INSERM, BPH, UMR1219, University Bordeaux, Bordeaux, F-33000, France.<br /><searchLink fieldCode="AU" term="%22Ducint+D%22">Ducint D</searchLink>; Department of Medical Pharmacology, CHU Bordeaux, Bordeaux, F-33000, France.<br /><searchLink fieldCode="AU" term="%22Molimard+M%22">Molimard M</searchLink>; Department of Medical Pharmacology, CHU Bordeaux, Bordeaux, F-33000, France.; INSERM, BPH, UMR1219, University Bordeaux, Bordeaux, F-33000, France.<br /><searchLink fieldCode="AU" term="%22Djabarouti+S%22">Djabarouti S</searchLink>; Department of Pharmacy, CHU Bordeaux, Pessac, F-33604, France. sarah.djabarouti@u-bordeaux.fr.; INSERM, BRIC, UMR1312, University Bordeaux, Bordeaux, F-33000, France. sarah.djabarouti@u-bordeaux.fr.<br /><searchLink fieldCode="AU" term="%22Guyon+J%22">Guyon J</searchLink>; INSERM, BRIC, UMR1312, University Bordeaux, Bordeaux, F-33000, France. joris.guyon@u-bordeaux.fr.; Department of Medical Pharmacology, CHU Bordeaux, Bordeaux, F-33000, France. joris.guyon@u-bordeaux.fr.; Department of Biochemistry, CHU Bordeaux, Bordeaux, F-33000, France. joris.guyon@u-bordeaux.fr.
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              Text: 2026 Jun 24
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