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Small-molecule modulation of β-arrestins.

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Title: Small-molecule modulation of β-arrestins.
Authors: Kahsai AW; Department of Medicine, Duke University Medical Center, Durham, NC, USA. alem@receptor-biol.duke.edu., Pakharukova N; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Kwon HY; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Department of Surgery, Henry Ford Hospital, Detroit, MI, USA., Shah KS; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Duke University School of Medicine, Duke University Medical Center, Durham, NC, USA.; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Del Real CT; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Shreiber BN; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Liang-Lin JG; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Shim PJ; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Lee MA; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Ngo VA; US Department of Energy, National Center for Computational Sciences, Oak Ridge National Laboratory, Oak Ridge, TN, USA., Schwalb AM; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Duke University School of Medicine, Duke University Medical Center, Durham, NC, USA., Pham U; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Department of Biochemistry, Duke University Medical Center, Durham, NC, USA., Chundi A; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Duke University School of Medicine, Duke University Medical Center, Durham, NC, USA., Jiang H; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Duke University School of Medicine, Duke University Medical Center, Durham, NC, USA., Flores-Espinoza E; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA., Liu S; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Nibley PC; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA., Bassford DK; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Hahn H; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA., Kunzle CA; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Thomas BN; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Kim J; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Zhou Y; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA., Wang J; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA., Zhang X; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Smith JS; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Departments of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Rein LAM; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Thomsen ARB; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA., Shenoy SK; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA., Rajagopal S; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Department of Biochemistry, Duke University Medical Center, Durham, NC, USA., Shi L; Computational Chemistry and Molecular Biophysics Section, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Ahn S; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Rockman HA; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA., Masoudi A; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Lefkowitz RJ; Department of Medicine, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu.; Department of Biochemistry, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu.; Department of Chemistry, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu.
Source: Nature [Nature] 2026 Jun 24. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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Department of Medicine, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Lefkowitz+RJ%22">Lefkowitz RJ</searchLink>; Department of Medicine, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu.; Department of Biochemistry, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu.; Department of Chemistry, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu.
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