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A Streptomyces megacluster encodes synergistic biotin-targeting antibiotics.

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Title: A Streptomyces megacluster encodes synergistic biotin-targeting antibiotics.
Authors: Gordzevich R; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., Xu M; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Science, Tianjin, China., Wang W; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., Cook MA; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., Hackenberger D; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., Deisinger JP; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., Tu MM; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., Carfrae LA; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., George M; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., Rachwalski K; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., Koteva K; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., Sychantha D; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada., Wei A; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., Wright GD; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca., Brown ED; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada. ebrown@mcmaster.ca.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. ebrown@mcmaster.ca.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada. ebrown@mcmaster.ca.
Source: Nature [Nature] 2026 Jul; Vol. 655 (8122), pp. 478-486. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: A Streptomyces megacluster encodes synergistic biotin-targeting antibiotics.
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  Data: <searchLink fieldCode="AU" term="%22Gordzevich+R%22">Gordzevich R</searchLink>; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Xu+M%22">Xu M</searchLink>; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Cook+MA%22">Cook MA</searchLink>; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hackenberger+D%22">Hackenberger D</searchLink>; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Deisinger+JP%22">Deisinger JP</searchLink>; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; 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Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wei+A%22">Wei A</searchLink>; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wright+GD%22">Wright GD</searchLink>; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.<br /><searchLink fieldCode="AU" term="%22Brown+ED%22">Brown ED</searchLink>; Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada. ebrown@mcmaster.ca.; Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. ebrown@mcmaster.ca.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada. ebrown@mcmaster.ca.
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