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Reciprocal signaling-metabolic crosstalk between fibroblasts and tumor cells drives cetuximab tolerance in head and neck cancers.

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Title: Reciprocal signaling-metabolic crosstalk between fibroblasts and tumor cells drives cetuximab tolerance in head and neck cancers.
Authors: Vigneron E; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium., Vignau J; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium., Lowyck O; Pole of Molecular Imaging, Radiotherapy and Oncology (MIRO), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, Brussels, B-1200, Belgium.; Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, Brussels, B-1200, Belgium., Van den Bossche V; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium.; Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, Brussels, B-1200, Belgium., Ambroise J; Centre des Technologies Moléculaires Appliquées (CTMA), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 54, Brussels, B-1200, Belgium., Kieffer Y; Stress and Cancer Laboratory, Equipe Labélisée Par La Ligue Nationale Contre Le Cancer, Inserm U1339 - UMR3666 CNRS, PSL Research University, Institute of Women's Cancer, Institut Curie, 26, rue d'Ulm, Paris, F-75248, France., Mechta-Grigoriou F; Stress and Cancer Laboratory, Equipe Labélisée Par La Ligue Nationale Contre Le Cancer, Inserm U1339 - UMR3666 CNRS, PSL Research University, Institute of Women's Cancer, Institut Curie, 26, rue d'Ulm, Paris, F-75248, France., Rizzi I; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium., Giolito MV; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium., Desgres M; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium., Zaryouh H; Center for Oncological Research (CORE), Integrated Personalized & Precision Oncology Network (IPPON), University of Antwerp, Universiteitsplein 1, Antwerp, B- 2610, Belgium., Wouters A; Center for Oncological Research (CORE), Integrated Personalized & Precision Oncology Network (IPPON), University of Antwerp, Universiteitsplein 1, Antwerp, B- 2610, Belgium., Mendola A; Pole of Molecular Imaging, Radiotherapy and Oncology (MIRO), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, Brussels, B-1200, Belgium., Dahou H; Pole of Molecular Imaging, Radiotherapy and Oncology (MIRO), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, Brussels, B-1200, Belgium., Leclerc M; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium., Boidot R; Unit of Molecular Biology, Department of Biology and Pathology of Tumors, Université Bourgogne Europe, Centre Georges-François Leclerc, Unicancer, ICMUB UMR CNRS 6302, Dijon, 21000, France., Warnant A; Louvain Institute of Biomolecular Science and Technology (LIBST), UCLouvain, Croix du Sud 4-5/L7.07.03, Louvain-la-Neuve, B-1348, Belgium., Larondelle Y; Louvain Institute of Biomolecular Science and Technology (LIBST), UCLouvain, Croix du Sud 4-5/L7.07.03, Louvain-la-Neuve, B-1348, Belgium., Feron O; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium.; WEL Research Institute, avenue Pasteur 6, Wavre, B-1300, Belgium., Machiels JP; Pole of Molecular Imaging, Radiotherapy and Oncology (MIRO), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, Brussels, B-1200, Belgium.; Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, Brussels, B-1200, Belgium., Schmitz S; Pole of Molecular Imaging, Radiotherapy and Oncology (MIRO), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, Brussels, B-1200, Belgium.; Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, Brussels, B-1200, Belgium., Corbet C; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium. cyril.corbet@uclouvain.be.; WEL Research Institute, avenue Pasteur 6, Wavre, B-1300, Belgium. cyril.corbet@uclouvain.be.
Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2026 Jun 24. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Reciprocal signaling-metabolic crosstalk between fibroblasts and tumor cells drives cetuximab tolerance in head and neck cancers.
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  Data: <searchLink fieldCode="AU" term="%22Vigneron+E%22">Vigneron E</searchLink>; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Vignau+J%22">Vignau J</searchLink>; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Lowyck+O%22">Lowyck O</searchLink>; Pole of Molecular Imaging, Radiotherapy and Oncology (MIRO), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, Brussels, B-1200, Belgium.; Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, Brussels, B-1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+den+Bossche+V%22">Van den Bossche V</searchLink>; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium.; Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, Brussels, B-1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Ambroise+J%22">Ambroise J</searchLink>; Centre des Technologies Moléculaires Appliquées (CTMA), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 54, Brussels, B-1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Kieffer+Y%22">Kieffer Y</searchLink>; Stress and Cancer Laboratory, Equipe Labélisée Par La Ligue Nationale Contre Le Cancer, Inserm U1339 - UMR3666 CNRS, PSL Research University, Institute of Women's Cancer, Institut Curie, 26, rue d'Ulm, Paris, F-75248, France.<br /><searchLink fieldCode="AU" term="%22Mechta-Grigoriou+F%22">Mechta-Grigoriou F</searchLink>; Stress and Cancer Laboratory, Equipe Labélisée Par La Ligue Nationale Contre Le Cancer, Inserm U1339 - UMR3666 CNRS, PSL Research University, Institute of Women's Cancer, Institut Curie, 26, rue d'Ulm, Paris, F-75248, France.<br /><searchLink fieldCode="AU" term="%22Rizzi+I%22">Rizzi I</searchLink>; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Giolito+MV%22">Giolito MV</searchLink>; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Desgres+M%22">Desgres M</searchLink>; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Zaryouh+H%22">Zaryouh H</searchLink>; Center for Oncological Research (CORE), Integrated Personalized & Precision Oncology Network (IPPON), University of Antwerp, Universiteitsplein 1, Antwerp, B- 2610, Belgium.<br /><searchLink fieldCode="AU" term="%22Wouters+A%22">Wouters A</searchLink>; Center for Oncological Research (CORE), Integrated Personalized & Precision Oncology Network (IPPON), University of Antwerp, Universiteitsplein 1, Antwerp, B- 2610, Belgium.<br /><searchLink fieldCode="AU" term="%22Mendola+A%22">Mendola A</searchLink>; Pole of Molecular Imaging, Radiotherapy and Oncology (MIRO), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, Brussels, B-1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Dahou+H%22">Dahou H</searchLink>; Pole of Molecular Imaging, Radiotherapy and Oncology (MIRO), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, Brussels, B-1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Leclerc+M%22">Leclerc M</searchLink>; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Boidot+R%22">Boidot R</searchLink>; Unit of Molecular Biology, Department of Biology and Pathology of Tumors, Université Bourgogne Europe, Centre Georges-François Leclerc, Unicancer, ICMUB UMR CNRS 6302, Dijon, 21000, France.<br /><searchLink fieldCode="AU" term="%22Warnant+A%22">Warnant A</searchLink>; Louvain Institute of Biomolecular Science and Technology (LIBST), UCLouvain, Croix du Sud 4-5/L7.07.03, Louvain-la-Neuve, B-1348, Belgium.<br /><searchLink fieldCode="AU" term="%22Larondelle+Y%22">Larondelle Y</searchLink>; Louvain Institute of Biomolecular Science and Technology (LIBST), UCLouvain, Croix du Sud 4-5/L7.07.03, Louvain-la-Neuve, B-1348, Belgium.<br /><searchLink fieldCode="AU" term="%22Feron+O%22">Feron O</searchLink>; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium.; WEL Research Institute, avenue Pasteur 6, Wavre, B-1300, Belgium.<br /><searchLink fieldCode="AU" term="%22Machiels+JP%22">Machiels JP</searchLink>; Pole of Molecular Imaging, Radiotherapy and Oncology (MIRO), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, Brussels, B-1200, Belgium.; Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, Brussels, B-1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Schmitz+S%22">Schmitz S</searchLink>; Pole of Molecular Imaging, Radiotherapy and Oncology (MIRO), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, Brussels, B-1200, Belgium.; Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, Brussels, B-1200, Belgium.<br /><searchLink fieldCode="AU" term="%22Corbet+C%22">Corbet C</searchLink>; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue Hippocrate 57, B1.57.04, Brussels, B-1200, Belgium. cyril.corbet@uclouvain.be.; WEL Research Institute, avenue Pasteur 6, Wavre, B-1300, Belgium. cyril.corbet@uclouvain.be.
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