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Risk-adapted HLA delisting and imlifidase-enabled deceased-donor kidney transplantation in highly sensitized kidney transplant candidates: a German expert consensus report.

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Title: Risk-adapted HLA delisting and imlifidase-enabled deceased-donor kidney transplantation in highly sensitized kidney transplant candidates: a German expert consensus report.
Authors: Reuter S; Department of Medicine D, Transplant Nephrology, University Hospital Münster, Münster, Germany.; Deutsche Transplantationsgesellschaft (DTG) Kidney Commission, Regensburg, Germany., Benning L; Department of Nephrology, Heidelberg University Hospital, Heidelberg, Germany., Dick A; Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, Laboratory for Immunogenetics and Molecular Diagnostics, Ludwig-Maximilians-Universität (LMU) University Hospital Munich, Munich, Germany., Dilz LM; Institute of Transfusion Medicine, Laboratory for Transplantation Immunology, Leipzig University Hospital, Leipzig, Germany., Einecke G; Department of Nephrology and Rheumatology, Section of Kidney Transplantation, University Medical Center Göttingen, Göttingen, Germany.; Deutsche Transplantationsgesellschaft (DTG) Immunology Commission, Regensburg, Germany.; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany., Emmerich F; Institute for Transfusion Medicine and Gene Therapy, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Grahammer F; III. Department of Medicine, Nephrology/Rheumatology/Endocrinology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Großmann R; Institute of Transfusion Medicine, Stem Cell Donor Registry Leipzig, Leipzig University Hospital, Leipzig, Germany., Gwinner W; Department of Nephrology, Hannover Medical School, Hannover, Germany., Halleck F; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany., Hallensleben M; Institute for Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany., Heinemann FM; Institute for Transfusion Medicine, Transplantation Diagnostics, University Hospital Essen, Essen, Germany., Jänigen B; Department of General and Visceral Surgery, Section of Transplantation Surgery, Medical Center - University of Freiburg, Freiburg, Germany., Kannenkeril D; Department of Medicine 4, Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany., Kauke T; Deutsche Transplantationsgesellschaft (DTG) Immunology Commission, Regensburg, Germany.; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Department of Thoracic Surgery, Lung Transplantation and Transplant Immunology, Ludwig-Maximilians-Universität (LMU) University Hospital Munich, Munich, Germany., Kelsch R; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Institute of Transfusion Medicine and Cell Therapy, Laboratory for Immunogenetics/Human Leukocyte Antigen (HLA), University Hospital Münster, Münster, Germany., Kemmner S; Transplant Center, LMU University Hospital Munich, Munich, Germany., Kluger MA; III. Department of Medicine, Nephrology/Rheumatology/Endocrinology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Kowald J; Division of Nephrology, Department of Endocrinology, Nephrology, and Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Kribben A; University Hospital Essen, Essen, Germany., Lehmann C; Institute of Transfusion Medicine, Transplant Immunology, University Hospital Hamburg, Hamburg, Germany., Lindemann M; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Institute for Transfusion Medicine, Transplantation Diagnostics, University Hospital Essen, Essen, Germany., Maccagno G; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Institute of Transfusion Medicine, Transplant Immunology, University Medical Center Mainz, Mainz, Germany., Morath C; Department of Nephrology and Hypertension, Nuremberg Hospital and Paracelsus Medical Private University, Nuremberg, Germany., Mühlfeld A; Deutsche Transplantationsgesellschaft (DTG) Kidney Commission, Regensburg, Germany.; Division of Nephrology and Immunology, Uniklinik Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany., Pham L; Institute for Immunology, Transplantation Immunology, University Hospital Heidelberg, Heidelberg, Germany., Renders L; Department of Nephrology, TUM University Hospital Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Schaub S; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Clinic for Nephrology and Transplantation Immunology, University Hospital Basel, Basel, Switzerland., Scherer S; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Institute for Immunology, Transplantation Immunology, University Hospital Heidelberg, Heidelberg, Germany., Seidl C; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Institute of Transfusion Medicine and Immunohematology, University Hospital Frankfurt, Frankfurt am Main, Germany., Spriewald B; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Laboratory of Immunogenetics (HLA Laboratory), Departments of Medicine 3 and 5, University Hospital Erlangen, Erlangen, Germany., Stippel D; Deutsche Transplantationsgesellschaft (DTG) Kidney Commission, Regensburg, Germany.; Department of General, Visceral, Tumor and Transplantation Surgery, University Hospital Cologne, Cologne, Germany., Stumpf J; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany., Tran TH; Institute for Immunology, Transplantation Immunology, University Hospital Heidelberg, Heidelberg, Germany., Weimer R; Department of Internal Medicine, Nephrology and Renal Transplantation, University Hospital of Giessen and Marburg, Giessen, Germany., Wilde B; Department of Infectious Diseases and Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Zecher D; Deutsche Transplantationsgesellschaft (DTG) Immunology Commission, Regensburg, Germany.; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Ziemann M; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Institute of Transfusion Medicine, University Hospital Schleswig-Holstein, Lübeck, Germany., Ziganshyna S; Organ Donation Coordinator Unit, University of Leipzig Medical Center, Leipzig, Germany., Lachmann N; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Institute of Transfusion Medicine, Tissue Typing/Human Leukocyte Antigen (HLA), Charité - Universitätsmedizin Berlin, Berlin, Germany., Budde K; Deutsche Transplantationsgesellschaft (DTG) Kidney Commission, Regensburg, Germany.; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Source: Frontiers in immunology [Front Immunol] 2026 Jun 09; Vol. 17, pp. 1846251. Date of Electronic Publication: 2026 Jun 09 (Print Publication: 2026).
Publication Type: Consensus Statement; Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Label: Title
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  Data: Risk-adapted HLA delisting and imlifidase-enabled deceased-donor kidney transplantation in highly sensitized kidney transplant candidates: a German expert consensus report.
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  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Reuter+S%22">Reuter S</searchLink>; Department of Medicine D, Transplant Nephrology, University Hospital Münster, Münster, Germany.; Deutsche Transplantationsgesellschaft (DTG) Kidney Commission, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Benning+L%22">Benning L</searchLink>; Department of Nephrology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Dick+A%22">Dick A</searchLink>; Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, Laboratory for Immunogenetics and Molecular Diagnostics, Ludwig-Maximilians-Universität (LMU) University Hospital Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Dilz+LM%22">Dilz LM</searchLink>; Institute of Transfusion Medicine, Laboratory for Transplantation Immunology, Leipzig University Hospital, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Einecke+G%22">Einecke G</searchLink>; Department of Nephrology and Rheumatology, Section of Kidney Transplantation, University Medical Center Göttingen, Göttingen, Germany.; Deutsche Transplantationsgesellschaft (DTG) Immunology Commission, Regensburg, Germany.; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Emmerich+F%22">Emmerich F</searchLink>; Institute for Transfusion Medicine and Gene Therapy, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Grahammer+F%22">Grahammer F</searchLink>; III. Department of Medicine, Nephrology/Rheumatology/Endocrinology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Großmann+R%22">Großmann R</searchLink>; Institute of Transfusion Medicine, Stem Cell Donor Registry Leipzig, Leipzig University Hospital, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Gwinner+W%22">Gwinner W</searchLink>; Department of Nephrology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Halleck+F%22">Halleck F</searchLink>; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hallensleben+M%22">Hallensleben M</searchLink>; Institute for Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Heinemann+FM%22">Heinemann FM</searchLink>; Institute for Transfusion Medicine, Transplantation Diagnostics, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Jänigen+B%22">Jänigen B</searchLink>; Department of General and Visceral Surgery, Section of Transplantation Surgery, Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kannenkeril+D%22">Kannenkeril D</searchLink>; Department of Medicine 4, Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Kauke+T%22">Kauke T</searchLink>; Deutsche Transplantationsgesellschaft (DTG) Immunology Commission, Regensburg, Germany.; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Department of Thoracic Surgery, Lung Transplantation and Transplant Immunology, Ludwig-Maximilians-Universität (LMU) University Hospital Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kelsch+R%22">Kelsch R</searchLink>; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Institute of Transfusion Medicine and Cell Therapy, Laboratory for Immunogenetics/Human Leukocyte Antigen (HLA), University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Kemmner+S%22">Kemmner S</searchLink>; Transplant Center, LMU University Hospital Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kluger+MA%22">Kluger MA</searchLink>; III. Department of Medicine, Nephrology/Rheumatology/Endocrinology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kowald+J%22">Kowald J</searchLink>; Division of Nephrology, Department of Endocrinology, Nephrology, and Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Kribben+A%22">Kribben A</searchLink>; University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Lehmann+C%22">Lehmann C</searchLink>; Institute of Transfusion Medicine, Transplant Immunology, University Hospital Hamburg, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lindemann+M%22">Lindemann M</searchLink>; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Institute for Transfusion Medicine, Transplantation Diagnostics, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Maccagno+G%22">Maccagno G</searchLink>; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Institute of Transfusion Medicine, Transplant Immunology, University Medical Center Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Morath+C%22">Morath C</searchLink>; Department of Nephrology and Hypertension, Nuremberg Hospital and Paracelsus Medical Private University, Nuremberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mühlfeld+A%22">Mühlfeld A</searchLink>; Deutsche Transplantationsgesellschaft (DTG) Kidney Commission, Regensburg, Germany.; Division of Nephrology and Immunology, Uniklinik Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Pham+L%22">Pham L</searchLink>; Institute for Immunology, Transplantation Immunology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Renders+L%22">Renders L</searchLink>; Department of Nephrology, TUM University Hospital Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schaub+S%22">Schaub S</searchLink>; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Clinic for Nephrology and Transplantation Immunology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Scherer+S%22">Scherer S</searchLink>; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Institute for Immunology, Transplantation Immunology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Seidl+C%22">Seidl C</searchLink>; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Institute of Transfusion Medicine and Immunohematology, University Hospital Frankfurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Spriewald+B%22">Spriewald B</searchLink>; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Laboratory of Immunogenetics (HLA Laboratory), Departments of Medicine 3 and 5, University Hospital Erlangen, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Stippel+D%22">Stippel D</searchLink>; Deutsche Transplantationsgesellschaft (DTG) Kidney Commission, Regensburg, Germany.; Department of General, Visceral, Tumor and Transplantation Surgery, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Stumpf+J%22">Stumpf J</searchLink>; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Tran+TH%22">Tran TH</searchLink>; Institute for Immunology, Transplantation Immunology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Weimer+R%22">Weimer R</searchLink>; Department of Internal Medicine, Nephrology and Renal Transplantation, University Hospital of Giessen and Marburg, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Wilde+B%22">Wilde B</searchLink>; Department of Infectious Diseases and Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Zecher+D%22">Zecher D</searchLink>; Deutsche Transplantationsgesellschaft (DTG) Immunology Commission, Regensburg, Germany.; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ziemann+M%22">Ziemann M</searchLink>; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Institute of Transfusion Medicine, University Hospital Schleswig-Holstein, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Ziganshyna+S%22">Ziganshyna S</searchLink>; Organ Donation Coordinator Unit, University of Leipzig Medical Center, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Lachmann+N%22">Lachmann N</searchLink>; Deutsche Gesellschaft für Immungenetik (DGI) Organ Transplantation Commission, Regensburg, Germany.; Institute of Transfusion Medicine, Tissue Typing/Human Leukocyte Antigen (HLA), Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Budde+K%22">Budde K</searchLink>; Deutsche Transplantationsgesellschaft (DTG) Kidney Commission, Regensburg, Germany.; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
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