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Placebo or active comparator in chronic migraine trials: Balancing evidence and practicality.

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Title: Placebo or active comparator in chronic migraine trials: Balancing evidence and practicality.
Authors: van Veelen N; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands., Ornello R; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Terwindt GM; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands., Sacco S; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Source: Cephalalgia : an international journal of headache [Cephalalgia] 2026 Jun; Vol. 46 (6), pp. 3331024261439282. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article; Review
Journal Info: Publisher: Country of Publication: England NLM ID: 8200710 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2982 (Electronic) Linking ISSN: 03331024 NLM ISO Abbreviation: Cephalalgia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22van+Veelen+N%22">van Veelen N</searchLink>; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ornello+R%22">Ornello R</searchLink>; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Terwindt+GM%22">Terwindt GM</searchLink>; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sacco+S%22">Sacco S</searchLink>; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
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  Data: <searchLink fieldCode="JN" term="%228200710%22">Cephalalgia : an international journal of headache</searchLink> [Cephalalgia] 2026 Jun; Vol. 46 (6), pp. 3331024261439282. <i>Date of Electronic Publication: </i>2026 Jun 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22%22"> </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8200710 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1468-2982 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203331024%22">03331024 </searchLink><i>NLM ISO Abbreviation: </i>Cephalalgia <i>Subsets: </i>MEDLINE
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        Value: 10.1177/03331024261439282
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        Text: English
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      – TitleFull: Placebo or active comparator in chronic migraine trials: Balancing evidence and practicality.
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              Text: 2026 Jun
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              Y: 2026
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