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Curcumin ((1E,6E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) Induces Apoptosis-like Death in Leishmania amazonensis Promastigotes and Exhibits Leishmanicidal Activity in Infected Macrophages in Free and Beeswax-Based Nanoparticle Formulations.

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Title: Curcumin ((1E,6E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) Induces Apoptosis-like Death in Leishmania amazonensis Promastigotes and Exhibits Leishmanicidal Activity in Infected Macrophages in Free and Beeswax-Based Nanoparticle Formulations.
Authors: Carloto ACM; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil., Rodrigues ACJ; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil., Detoni MB; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil., Cruz EMS; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil., Concato-Lopes VM; Cedars-Sinai Medical Center, Cedars-Sinai, Los Angeles, CA 90048, USA., Balbinot RB; Laboratory for Technological Innovation, Development of Pharmaceuticals and Cosmetics, State University of Maringá, Maringá 87020-900, PR, Brazil., Inoue FSR; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil., Barreiros Y; Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil., Cordeiro AP; Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil., Hermes de Araújo PH; Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil., Sayer C; Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil., Feuser PE; Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil., Nakamura CV; Laboratory for Technological Innovation, Development of Pharmaceuticals and Cosmetics, State University of Maringá, Maringá 87020-900, PR, Brazil., Conchon-Costa I; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil., Lazarin-Bidóia D; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil.; Laboratory for Technological Innovation, Development of Pharmaceuticals and Cosmetics, State University of Maringá, Maringá 87020-900, PR, Brazil., Pavanelli WR; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil.
Source: Pathogens (Basel, Switzerland) [Pathogens] 2026 Jun 20; Vol. 15 (6). Date of Electronic Publication: 2026 Jun 20.
Publication Type: Journal Article
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-0817 (Electronic) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Curcumin ((1E,6E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) Induces Apoptosis-like Death in Leishmania amazonensis Promastigotes and Exhibits Leishmanicidal Activity in Infected Macrophages in Free and Beeswax-Based Nanoparticle Formulations.
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  Data: <searchLink fieldCode="AU" term="%22Carloto+ACM%22">Carloto ACM</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Rodrigues+ACJ%22">Rodrigues ACJ</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Detoni+MB%22">Detoni MB</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Cruz+EMS%22">Cruz EMS</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Concato-Lopes+VM%22">Concato-Lopes VM</searchLink>; Cedars-Sinai Medical Center, Cedars-Sinai, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Balbinot+RB%22">Balbinot RB</searchLink>; Laboratory for Technological Innovation, Development of Pharmaceuticals and Cosmetics, State University of Maringá, Maringá 87020-900, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Inoue+FSR%22">Inoue FSR</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Barreiros+Y%22">Barreiros Y</searchLink>; Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Cordeiro+AP%22">Cordeiro AP</searchLink>; Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Hermes+de+Araújo+PH%22">Hermes de Araújo PH</searchLink>; Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Sayer+C%22">Sayer C</searchLink>; Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Feuser+PE%22">Feuser PE</searchLink>; Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Nakamura+CV%22">Nakamura CV</searchLink>; Laboratory for Technological Innovation, Development of Pharmaceuticals and Cosmetics, State University of Maringá, Maringá 87020-900, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Conchon-Costa+I%22">Conchon-Costa I</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Lazarin-Bidóia+D%22">Lazarin-Bidóia D</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil.; Laboratory for Technological Innovation, Development of Pharmaceuticals and Cosmetics, State University of Maringá, Maringá 87020-900, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Pavanelli+WR%22">Pavanelli WR</searchLink>; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, Londrina 86057-970, PR, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101596317%22">Pathogens (Basel, Switzerland)</searchLink> [Pathogens] 2026 Jun 20; Vol. 15 (6). <i>Date of Electronic Publication: </i>2026 Jun 20.
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