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Variability in epilepsy polygenic risk prediction across Taiwanese population and clinical cohorts.

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Title: Variability in epilepsy polygenic risk prediction across Taiwanese population and clinical cohorts.
Authors: Ke YS; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan., Tsai MH; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Doctoral Program of Clinical and Experimental Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan., Ho CR; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan., Chou CY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen HH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Stevelink R; Department of Child Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, European Reference Network EpiCARE, Utrecht, the Netherlands.; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, European Reference Network EpiCARE, Utrecht, the Netherlands., Chen S; Department of Human Genetics, University of Chicago, Chicago, Illinois, USA., Chen PC; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Liu YT; Division of Epilepsy, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Institute of Brain Science, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Tung H; Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Post-Baccalaureate Medicine, National Chung Hsing University, Taichung, Taiwan., Hsiao TH; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Public Health, Fu Jen Catholic University, New Taipei City, Taiwan.; Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, Taiwan., Tseng SH; Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan., Chan L; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Neurology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan., Lee TH; Department of Neurology, Linkou Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan., Cheng CK; Department of Neurology, Linkou Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan., Jeng JS; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan., Lin CH; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.; College of Medicine, National Taiwan University, Taipei, Taiwan., Hsu CY; Department of Neurology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan., Yang YH; Department of Neurology, Kaohsiung Medical University Gangshan Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan., Yang SF; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan., Fan YC; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Neurology, Chung Shan Medical University Hospital, Taichung, Taiwan., Yang FC; Department of Neurology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan., Sung YF; Department of Neurology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan., Lin SZ; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan., Wang TF; Department of Hematology and Oncology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan., Liu YH; Division of Cardiology, Cardiovascular Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan., Chu YC; Department of Neurology, Far Eastern Memorial Hospital, New Taipei City, Taiwan., Chen M; Department of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan., Chang MY; Division of Pediatric Neurology, Department of Pediatrics, Changhua Christian Children Hospital and Changhua Christian Hospital, Changhua, Taiwan., Lee SL; Division of Endocrinology, Department of Internal Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan., Chang CC; Department of Neurology, Fu Jen Catholic University Hospital, New Taipei City, Taiwan.; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan., Huang YC; Department of Neurology, Fu Jen Catholic University Hospital, New Taipei City, Taiwan., Cheng WM; Department of Urology, College of Medicine and Shu-Tien Urological Research Center, National Yang-Ming Chiao Tung University, Taipei, Taiwan.; Division of Urology, Taipei City Hospital Zhongxiao Branch, Taipei, Taiwan., Chen SS; Department of Urology, College of Medicine and Shu-Tien Urological Research Center, National Yang-Ming Chiao Tung University, Taipei, Taiwan.; Division of Urology, Taipei City Hospital Ren Ai Branch, Taipei, Taiwan.; University of Taipei, General Education Center, Taipei, Taiwan., Su YH; Division of Neurology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan., Sung SF; Division of Neurology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan., Lee MC; Department of Neurology, Cathay General Hospital, Taipei, Taiwan., Chen JT; Department of Neurology, Cathay General Hospital, Taipei, Taiwan., Feng YA; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan.; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan.
Source: Epilepsia [Epilepsia] 2026 Jun 25. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Variability in epilepsy polygenic risk prediction across Taiwanese population and clinical cohorts.
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  Data: <searchLink fieldCode="AU" term="%22Ke+YS%22">Ke YS</searchLink>; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+MH%22">Tsai MH</searchLink>; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Doctoral Program of Clinical and Experimental Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ho+CR%22">Ho CR</searchLink>; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chou+CY%22">Chou CY</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+HH%22">Chen HH</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Stevelink+R%22">Stevelink R</searchLink>; Department of Child Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, European Reference Network EpiCARE, Utrecht, the Netherlands.; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, European Reference Network EpiCARE, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Department of Human Genetics, University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Chen+PC%22">Chen PC</searchLink>; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+YT%22">Liu YT</searchLink>; Division of Epilepsy, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Institute of Brain Science, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tung+H%22">Tung H</searchLink>; Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Post-Baccalaureate Medicine, National Chung Hsing University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsiao+TH%22">Hsiao TH</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Public Health, Fu Jen Catholic University, New Taipei City, Taiwan.; Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tseng+SH%22">Tseng SH</searchLink>; Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chan+L%22">Chan L</searchLink>; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Neurology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+TH%22">Lee TH</searchLink>; Department of Neurology, Linkou Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+CK%22">Cheng CK</searchLink>; Department of Neurology, Linkou Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jeng+JS%22">Jeng JS</searchLink>; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CH%22">Lin CH</searchLink>; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.; College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+CY%22">Hsu CY</searchLink>; Department of Neurology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+YH%22">Yang YH</searchLink>; Department of Neurology, Kaohsiung Medical University Gangshan Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+SF%22">Yang SF</searchLink>; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fan+YC%22">Fan YC</searchLink>; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Neurology, Chung Shan Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+FC%22">Yang FC</searchLink>; Department of Neurology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sung+YF%22">Sung YF</searchLink>; Department of Neurology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+SZ%22">Lin SZ</searchLink>; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+TF%22">Wang TF</searchLink>; Department of Hematology and Oncology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+YH%22">Liu YH</searchLink>; Division of Cardiology, Cardiovascular Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chu+YC%22">Chu YC</searchLink>; Department of Neurology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; Department of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+MY%22">Chang MY</searchLink>; Division of Pediatric Neurology, Department of Pediatrics, Changhua Christian Children Hospital and Changhua Christian Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+SL%22">Lee SL</searchLink>; Division of Endocrinology, Department of Internal Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+CC%22">Chang CC</searchLink>; Department of Neurology, Fu Jen Catholic University Hospital, New Taipei City, Taiwan.; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+YC%22">Huang YC</searchLink>; Department of Neurology, Fu Jen Catholic University Hospital, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+WM%22">Cheng WM</searchLink>; Department of Urology, College of Medicine and Shu-Tien Urological Research Center, National Yang-Ming Chiao Tung University, Taipei, Taiwan.; Division of Urology, Taipei City Hospital Zhongxiao Branch, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+SS%22">Chen SS</searchLink>; Department of Urology, College of Medicine and Shu-Tien Urological Research Center, National Yang-Ming Chiao Tung University, Taipei, Taiwan.; Division of Urology, Taipei City Hospital Ren Ai Branch, Taipei, Taiwan.; University of Taipei, General Education Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Su+YH%22">Su YH</searchLink>; Division of Neurology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sung+SF%22">Sung SF</searchLink>; Division of Neurology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+MC%22">Lee MC</searchLink>; Department of Neurology, Cathay General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+JT%22">Chen JT</searchLink>; Department of Neurology, Cathay General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Feng+YA%22">Feng YA</searchLink>; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan.; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan.
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