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A Phase 2 Feasibility Study Combining Pembrolizumab and Metformin in patients with Metastatic Head and Neck Cancer.

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Title: A Phase 2 Feasibility Study Combining Pembrolizumab and Metformin in patients with Metastatic Head and Neck Cancer.
Authors: Zamulko O; University of Cincinnati Cincinnati, Ohio United States., Nusbaum S; University of Cincinnati Cincinnati, OH United States., Osterburg A; University of Cincinnati Cincinnati, OH United States., Crist M; University of Cincinnati Cincinnati, OH United States., Lehn M; University of Cincinnati Cincinnati, OH United States., Monroe I; University of Cincinnati Cincinnati, OH United States., Romano A; University of Cincinnati Cincinnati, OH United States., Allen CL; University of Cincinnati Cincinnati, OH United States., Forsythe A; University of Cincinnati Medical Center Cincinnati, Ohio United States., Riaz MK; University of Cincinnati Cincinnati, OH United States., Lemmon C; University of Cincinnati Medical Center Cincinnati, Ohio United States., Takiar V; University of Cincinnati Cincinnati, OH United States., Pan J; University of Cincinnati Cincinnati, OH United States., Rai SN; University of Cincinnati Cincinnati, OH United States., Borchers M; University of Cincinnati Cincinnati, OH United States., El-Gamal D; University of Cincinnati Medical Center Cincinnati, OH United States., Wise-Draper T; University of Cincinnati Cincinnati, OH United States.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2026 Jun 25. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A Phase 2 Feasibility Study Combining Pembrolizumab and Metformin in patients with Metastatic Head and Neck Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Zamulko+O%22">Zamulko O</searchLink>; University of Cincinnati Cincinnati, Ohio United States.<br /><searchLink fieldCode="AU" term="%22Nusbaum+S%22">Nusbaum S</searchLink>; University of Cincinnati Cincinnati, OH United States.<br /><searchLink fieldCode="AU" term="%22Osterburg+A%22">Osterburg A</searchLink>; University of Cincinnati Cincinnati, OH United States.<br /><searchLink fieldCode="AU" term="%22Crist+M%22">Crist M</searchLink>; University of Cincinnati Cincinnati, OH United States.<br /><searchLink fieldCode="AU" term="%22Lehn+M%22">Lehn M</searchLink>; University of Cincinnati Cincinnati, OH United States.<br /><searchLink fieldCode="AU" term="%22Monroe+I%22">Monroe I</searchLink>; University of Cincinnati Cincinnati, OH United States.<br /><searchLink fieldCode="AU" term="%22Romano+A%22">Romano A</searchLink>; University of Cincinnati Cincinnati, OH United States.<br /><searchLink fieldCode="AU" term="%22Allen+CL%22">Allen CL</searchLink>; University of Cincinnati Cincinnati, OH United States.<br /><searchLink fieldCode="AU" term="%22Forsythe+A%22">Forsythe A</searchLink>; University of Cincinnati Medical Center Cincinnati, Ohio United States.<br /><searchLink fieldCode="AU" term="%22Riaz+MK%22">Riaz MK</searchLink>; University of Cincinnati Cincinnati, OH United States.<br /><searchLink fieldCode="AU" term="%22Lemmon+C%22">Lemmon C</searchLink>; University of Cincinnati Medical Center Cincinnati, Ohio United States.<br /><searchLink fieldCode="AU" term="%22Takiar+V%22">Takiar V</searchLink>; University of Cincinnati Cincinnati, OH United States.<br /><searchLink fieldCode="AU" term="%22Pan+J%22">Pan J</searchLink>; University of Cincinnati Cincinnati, OH United States.<br /><searchLink fieldCode="AU" term="%22Rai+SN%22">Rai SN</searchLink>; University of Cincinnati Cincinnati, OH United States.<br /><searchLink fieldCode="AU" term="%22Borchers+M%22">Borchers M</searchLink>; University of Cincinnati Cincinnati, OH United States.<br /><searchLink fieldCode="AU" term="%22El-Gamal+D%22">El-Gamal D</searchLink>; University of Cincinnati Medical Center Cincinnati, OH United States.<br /><searchLink fieldCode="AU" term="%22Wise-Draper+T%22">Wise-Draper T</searchLink>; University of Cincinnati Cincinnati, OH United States.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2026 Jun 25. <i>Date of Electronic Publication: </i>2026 Jun 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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        Value: 10.1158/1078-0432.CCR-26-0874
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        Text: English
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      – TitleFull: A Phase 2 Feasibility Study Combining Pembrolizumab and Metformin in patients with Metastatic Head and Neck Cancer.
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              Text: 2026 Jun 25
              Type: published
              Y: 2026
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