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Cellular senescence links muscle atrophy and posttraumatic osteoarthritis after ACL injury.

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Title: Cellular senescence links muscle atrophy and posttraumatic osteoarthritis after ACL injury.
Authors: Keeble AR; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Owen AM; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States., Gonzalez-Velez S; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Thomas NT; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States., Brightwell CR; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States., Balawender PJ; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States., O'Daniel MG; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States., Weiss HC; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States., Noehren H; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States., Thompson H; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Biomedical Engineering, College of Engineering, University of Kentucky, Lexington, Kentucky, United States., Zuluaga-Osorio KS; Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Bates ZT; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States., Gottlieb L; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States., Long DE; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States., Harrison DA; Department of Biology, College of Arts and Sciences, University of Kentucky, Lexington, Kentucky, United States., Kern PA; Division of Endocrinology, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Conley CE; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Samaan MA; Department of Kinesiology and Health Promotion, College of Education, University of Kentucky, Lexington, Kentucky, United States., Duncan ST; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Stone AV; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Johnson DL; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Wen Y; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Noehren B; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Dungan CM; Department of Health, Human Performance, and Recreation, College of Health and Human Sciences, Baylor University, Waco, Texas, United States., Fry CS; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.
Source: Function (Oxford, England) [Function (Oxf)] 2026 Aug 01; Vol. 7 (4), pp. e0172026. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 101770668 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2633-8823 (Electronic) Linking ISSN: 26338823 NLM ISO Abbreviation: Function (Oxf) Subsets: MEDLINE
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  Data: Cellular senescence links muscle atrophy and posttraumatic osteoarthritis after ACL injury.
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  Data: <searchLink fieldCode="AU" term="%22Keeble+AR%22">Keeble AR</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Owen+AM%22">Owen AM</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Velez+S%22">Gonzalez-Velez S</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Thomas+NT%22">Thomas NT</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Brightwell+CR%22">Brightwell CR</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Balawender+PJ%22">Balawender PJ</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22O'Daniel+MG%22">O'Daniel MG</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Weiss+HC%22">Weiss HC</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Noehren+H%22">Noehren H</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Thompson+H%22">Thompson H</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Biomedical Engineering, College of Engineering, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Zuluaga-Osorio+KS%22">Zuluaga-Osorio KS</searchLink>; Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Bates+ZT%22">Bates ZT</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Gottlieb+L%22">Gottlieb L</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Long+DE%22">Long DE</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Harrison+DA%22">Harrison DA</searchLink>; Department of Biology, College of Arts and Sciences, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Kern+PA%22">Kern PA</searchLink>; Division of Endocrinology, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Conley+CE%22">Conley CE</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Samaan+MA%22">Samaan MA</searchLink>; Department of Kinesiology and Health Promotion, College of Education, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Duncan+ST%22">Duncan ST</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Stone+AV%22">Stone AV</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Johnson+DL%22">Johnson DL</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Wen+Y%22">Wen Y</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Noehren+B%22">Noehren B</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.<br /><searchLink fieldCode="AU" term="%22Dungan+CM%22">Dungan CM</searchLink>; Department of Health, Human Performance, and Recreation, College of Health and Human Sciences, Baylor University, Waco, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Fry+CS%22">Fry CS</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.
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  Data: <searchLink fieldCode="JN" term="%22101770668%22">Function (Oxford, England)</searchLink> [Function (Oxf)] 2026 Aug 01; Vol. 7 (4), pp. e0172026. <i>Date of Electronic Publication: </i>2026 Jun 25.
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