The calcium pump ATP2B1/PMCA1 regulates CNS vascular development by facilitating Norrin- and WNT7A/B-induced Frizzled4 signaling.

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Title: The calcium pump ATP2B1/PMCA1 regulates CNS vascular development by facilitating Norrin- and WNT7A/B-induced Frizzled4 signaling.
Authors: Jo HN; University of Minnesota, Graduate Program in Molecular, Cellular, Developmental Biology, and Genetics, Minneapolis, MN, USA; University of Minnesota, Department of Ophthalmology and Visual Neurosciences, Minneapolis, MN, USA., Kiffmeyer E; University of Minnesota, Department of Neuroscience, Minneapolis, MN, USA., Zhang C; Department of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA., Zhang L; University of Minnesota, Department of Ophthalmology and Visual Neurosciences, Minneapolis, MN, USA; University of St. Thomas, Department of Biology, Saint Paul, MN, USA., Odame E; University of Minnesota, Graduate Program in Molecular, Cellular, Developmental Biology, and Genetics, Minneapolis, MN, USA; University of Minnesota, Department of Ophthalmology and Visual Neurosciences, Minneapolis, MN, USA., Dinh QC; University of Minnesota, Department of Ophthalmology and Visual Neurosciences, Minneapolis, MN, USA., Levey J; University of Minnesota, Graduate Program in Molecular, Cellular, Developmental Biology, and Genetics, Minneapolis, MN, USA; University of Minnesota, Department of Ophthalmology and Visual Neurosciences, Minneapolis, MN, USA., Howe M; University of Minnesota, Graduate Program in Molecular, Cellular, Developmental Biology, and Genetics, Minneapolis, MN, USA; University of Minnesota, Department of Ophthalmology and Visual Neurosciences, Minneapolis, MN, USA., Roux KJ; Enabling Technology Group, Sanford Research, Sioux Falls, SD, USA; Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA., Fischer KD; Institute for Biochemistry and Cell Biology, Otto-von-Guericke University, Medical Faculty, Magdeburg, Germany., Chen Z; University of Minnesota, Department of Neuroscience, Minneapolis, MN, USA., Junge HJ; University of Minnesota, Graduate Program in Molecular, Cellular, Developmental Biology, and Genetics, Minneapolis, MN, USA; University of Minnesota, Department of Ophthalmology and Visual Neurosciences, Minneapolis, MN, USA. Electronic address: junge@umn.edu.
Source: Cell reports [Cell Rep] 2026 Jun 25; Vol. 45 (7), pp. 117605. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2211-1247
DOI:10.1016/j.celrep.2026.117605