The calcium pump ATP2B1/PMCA1 regulates CNS vascular development by facilitating Norrin- and WNT7A/B-induced Frizzled4 signaling. - Jo HN; Kiffmeyer E; Zhang C; Zhang L; Odame E; Dinh QC; Levey J; Howe M; Roux KJ; Fischer KD; Chen Z; Junge HJ (Cell reports, 2026)