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Steps against the burden of Parkinson's disease (StepuP): Protocol of a randomized controlled trial elucidating the biomechanical and neurophysiological mechanisms of a speed dependent treadmill training intervention.

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Title: Steps against the burden of Parkinson's disease (StepuP): Protocol of a randomized controlled trial elucidating the biomechanical and neurophysiological mechanisms of a speed dependent treadmill training intervention.
Authors: van Leeuwen AM; Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands., Welzel J; Department of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany., D'Ascanio I; Department of Electrical, Electronic, and Information Engineering 'Guglielmo Marconi', University of Bologna, Bologna, Italy., Lang C; Institute for Biomechanics, ETH Zürich, Zürich, Switzerland., Vinod V; Department of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany., Görrisen P; Department of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany., Geritz J; Department of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany., Hansen C; Department of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany., Gazit E; Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Israel., Tov SS; Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Israel., Prusak R; Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Israel., Casadei I; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy., Contri A; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy., Tampellini F; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy., Pellicciari L; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy., Lopane G; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy., Buonaura GC; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy., Palmerini L; Department of Electrical, Electronic, and Information Engineering 'Guglielmo Marconi', University of Bologna, Bologna, Italy., Zahid N; University of New South Wales, Sydney, Australia., Mehwish M; University of New South Wales, Sydney, Australia., Ratanapongleka M; University of New South Wales, Sydney, Australia., Razee H; University of New South Wales, Sydney, Australia., von Wegner F; University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Sydney, Australia., van Wijk BCM; Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.; Department of Neurology, Amsterdam University Medical Center, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, the Netherlands., Bruijn SM; Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands., Ravi DK; Institute for Biomechanics, ETH Zürich, Zürich, Switzerland., Okubo Y; University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Sydney, Australia., Singh NB; Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.; Future Health Technologies Programme, Singapore-ETH Centre, Singapore., Brodie M; University of New South Wales, Sydney, Australia., La Porta F; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy., Hausdorff JM; Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Israel.; Department of Physical Therapy, Gray Faculty of Medical & Health Sciences & Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Rush Alzheimer's Disease Center, Rush University Medical Center and Department of Orthopaedic Surgery, Rush Medical College, Chicago, USA., Maetzler W; Department of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany., van Dieën JH; Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.
Source: PloS one [PLoS One] 2026 Jun 25; Vol. 21 (6), pp. e0348957. Date of Electronic Publication: 2026 Jun 25 (Print Publication: 2026).
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Steps against the burden of Parkinson's disease (StepuP): Protocol of a randomized controlled trial elucidating the biomechanical and neurophysiological mechanisms of a speed dependent treadmill training intervention.
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  Data: <searchLink fieldCode="AU" term="%22van+Leeuwen+AM%22">van Leeuwen AM</searchLink>; Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Welzel+J%22">Welzel J</searchLink>; Department of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22D'Ascanio+I%22">D'Ascanio I</searchLink>; Department of Electrical, Electronic, and Information Engineering 'Guglielmo Marconi', University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Lang+C%22">Lang C</searchLink>; Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vinod+V%22">Vinod V</searchLink>; Department of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Görrisen+P%22">Görrisen P</searchLink>; Department of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Geritz+J%22">Geritz J</searchLink>; Department of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Hansen+C%22">Hansen C</searchLink>; Department of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Gazit+E%22">Gazit E</searchLink>; Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Israel.<br /><searchLink fieldCode="AU" term="%22Tov+SS%22">Tov SS</searchLink>; Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Israel.<br /><searchLink fieldCode="AU" term="%22Prusak+R%22">Prusak R</searchLink>; Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Israel.<br /><searchLink fieldCode="AU" term="%22Casadei+I%22">Casadei I</searchLink>; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Contri+A%22">Contri A</searchLink>; 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University of New South Wales, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Ratanapongleka+M%22">Ratanapongleka M</searchLink>; University of New South Wales, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Razee+H%22">Razee H</searchLink>; University of New South Wales, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22von+Wegner+F%22">von Wegner F</searchLink>; University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22van+Wijk+BCM%22">van Wijk BCM</searchLink>; Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.; Department of Neurology, Amsterdam University Medical Center, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bruijn+SM%22">Bruijn SM</searchLink>; Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Ravi+DK%22">Ravi DK</searchLink>; Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Okubo+Y%22">Okubo Y</searchLink>; University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Singh+NB%22">Singh NB</searchLink>; Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.; Future Health Technologies Programme, Singapore-ETH Centre, Singapore.<br /><searchLink fieldCode="AU" term="%22Brodie+M%22">Brodie M</searchLink>; University of New South Wales, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22La+Porta+F%22">La Porta F</searchLink>; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Hausdorff+JM%22">Hausdorff JM</searchLink>; Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Israel.; Department of Physical Therapy, Gray Faculty of Medical & Health Sciences & Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Rush Alzheimer's Disease Center, Rush University Medical Center and Department of Orthopaedic Surgery, Rush Medical College, Chicago, USA.<br /><searchLink fieldCode="AU" term="%22Maetzler+W%22">Maetzler W</searchLink>; Department of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22van+Dieën+JH%22">van Dieën JH</searchLink>; Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.
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