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Single-cell multiomics of neuron activation reveals context-specific genetics of brain disorders.

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Title: Single-cell multiomics of neuron activation reveals context-specific genetics of brain disorders.
Authors: Liang L; Department of Human Genetics, The University of Chicago, Chicago, IL, USA., Zhang S; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA., Wang Z; Department of Human Genetics, The University of Chicago, Chicago, IL, USA., Zhang H; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA., Li C; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.; Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Thapa C; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA., Oh EK; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA., Sirkin D; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA., Sun X; Department of Human Genetics, The University of Chicago, Chicago, IL, USA., Barishman A; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA., McCarroll A; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA., Duhe AC; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA., Qian S; Department of Human Genetics, The University of Chicago, Chicago, IL, USA., Zhong X; Department of Human Genetics, The University of Chicago, Chicago, IL, USA., Jamison B; Department of Human Genetics, The University of Chicago, Chicago, IL, USA.; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA., Wood W; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA., Kozlova A; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA., Pang ZP; Center for NeuroMetabolism, Department of Neuroscience and Cell Biology, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Sanders AR; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA., He X; Department of Human Genetics, The University of Chicago, Chicago, IL, USA., Duan J; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.
Source: Science (New York, N.Y.) [Science] 2026 Jun 25; Vol. 392 (6805), pp. eadw3949. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Single-cell multiomics of neuron activation reveals context-specific genetics of brain disorders.
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  Data: <searchLink fieldCode="AU" term="%22Liang+L%22">Liang L</searchLink>; Department of Human Genetics, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Human Genetics, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.; Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Thapa+C%22">Thapa C</searchLink>; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Oh+EK%22">Oh EK</searchLink>; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Sirkin+D%22">Sirkin D</searchLink>; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; Department of Human Genetics, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Barishman+A%22">Barishman A</searchLink>; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22McCarroll+A%22">McCarroll A</searchLink>; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Duhe+AC%22">Duhe AC</searchLink>; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Qian+S%22">Qian S</searchLink>; Department of Human Genetics, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Zhong+X%22">Zhong X</searchLink>; Department of Human Genetics, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Jamison+B%22">Jamison B</searchLink>; Department of Human Genetics, The University of Chicago, Chicago, IL, USA.; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Wood+W%22">Wood W</searchLink>; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Kozlova+A%22">Kozlova A</searchLink>; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Pang+ZP%22">Pang ZP</searchLink>; Center for NeuroMetabolism, Department of Neuroscience and Cell Biology, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Sanders+AR%22">Sanders AR</searchLink>; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22He+X%22">He X</searchLink>; Department of Human Genetics, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Duan+J%22">Duan J</searchLink>; Center for Psychiatric Genetics, Endeavor Health Research Institute, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2026 Jun 25; Vol. 392 (6805), pp. eadw3949. <i>Date of Electronic Publication: </i>2026 Jun 25.
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