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A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells.

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Title: A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells.
Authors: Duggal G; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Oxford StemTech, The Oxford Science Park, Oxford, UK. Electronic address: galbha.duggal@oxfordstemtech.com., Li X; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Pettingill P; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Lalic T; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Gupta SK; Global Portfolio & Project Management, Oncology R&D, Cambridge, UK., Høgsbro CF; Department of Neurology, Faculty of Health and Medical Sciences, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark., Volpato V; UK Dementia Research Institute, Department of Psychological Medicine and Clinical Neuroscience, Cardiff University, Cardiff, UK., Webber C; UK Dementia Research Institute, Department of Psychological Medicine and Clinical Neuroscience, Cardiff University, Cardiff, UK., Bowden R; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Charou D; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Arunasalam K; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Maresca M; Discovery Biology, Discovery Sciences IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., Hicks R; Bioanalytical and Biomarker Labs, Thermofisher Scientific, Gothenburg, Sweden., Chintawar S; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Oxford StemTech, The Oxford Science Park, Oxford, UK., Cader MZ; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Oxford StemTech, The Oxford Science Park, Oxford, UK. Electronic address: zameel.cader@ndcn.ox.ac.uk.
Source: Stem cell reports [Stem Cell Reports] 2026 Jul 14; Vol. 21 (7), pp. 102971. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
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  Data: A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells.
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  Data: <searchLink fieldCode="AU" term="%22Duggal+G%22">Duggal G</searchLink>; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Oxford StemTech, The Oxford Science Park, Oxford, UK. Electronic address: galbha.duggal@oxfordstemtech.com.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Pettingill+P%22">Pettingill P</searchLink>; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lalic+T%22">Lalic T</searchLink>; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Gupta+SK%22">Gupta SK</searchLink>; Global Portfolio & Project Management, Oncology R&D, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Høgsbro+CF%22">Høgsbro CF</searchLink>; Department of Neurology, Faculty of Health and Medical Sciences, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark.<br /><searchLink fieldCode="AU" term="%22Volpato+V%22">Volpato V</searchLink>; UK Dementia Research Institute, Department of Psychological Medicine and Clinical Neuroscience, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Webber+C%22">Webber C</searchLink>; UK Dementia Research Institute, Department of Psychological Medicine and Clinical Neuroscience, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Bowden+R%22">Bowden R</searchLink>; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Charou+D%22">Charou D</searchLink>; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Arunasalam+K%22">Arunasalam K</searchLink>; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Maresca+M%22">Maresca M</searchLink>; Discovery Biology, Discovery Sciences IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Hicks+R%22">Hicks R</searchLink>; Bioanalytical and Biomarker Labs, Thermofisher Scientific, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Chintawar+S%22">Chintawar S</searchLink>; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Oxford StemTech, The Oxford Science Park, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cader+MZ%22">Cader MZ</searchLink>; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Oxford StemTech, The Oxford Science Park, Oxford, UK. Electronic address: zameel.cader@ndcn.ox.ac.uk.
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