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WISP-3 drives LUAD metastasis by suppressing miR-5004-5p to upregulate MMP-12.

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Title: WISP-3 drives LUAD metastasis by suppressing miR-5004-5p to upregulate MMP-12.
Authors: Chao CC; Department of Respiratory Therapy, Fu Jen Catholic University, New Taipei City, Taiwan; Center for Health Research and Innovation, Fu Jen Catholic University, New Taipei City, Taiwan., Lee CW; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan; Chronic Diseases and Health Promotion Research Center and Center for Smart Healthcare Education and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi, Taiwan; Department of Safety Health and Environmental Engineering, Ming Chi University of Technology, New Taipei City, Taiwan., Lin SL; Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan., Chen YC; Translational Medicine Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan., Cheng CY; Division of Chest Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan., Chang EM; Department of Respiratory Care, Shin Kong Wu Ho-Su Memorial Hospital, Taipei City, Taiwan., Tang CH; Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan; Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung, Taiwan., Lin CY; Translational Medicine Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan. Electronic address: T016406@ms.skh.org.tw.
Source: Biochemical pharmacology [Biochem Pharmacol] 2026 Sep; Vol. 251 (Pt 2), pp. 118189. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: WISP-3 drives LUAD metastasis by suppressing miR-5004-5p to upregulate MMP-12.
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  Data: <searchLink fieldCode="AU" term="%22Chao+CC%22">Chao CC</searchLink>; Department of Respiratory Therapy, Fu Jen Catholic University, New Taipei City, Taiwan; Center for Health Research and Innovation, Fu Jen Catholic University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+CW%22">Lee CW</searchLink>; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan; Chronic Diseases and Health Promotion Research Center and Center for Smart Healthcare Education and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi, Taiwan; Department of Safety Health and Environmental Engineering, Ming Chi University of Technology, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+SL%22">Lin SL</searchLink>; Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YC%22">Chen YC</searchLink>; Translational Medicine Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+CY%22">Cheng CY</searchLink>; Division of Chest Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+EM%22">Chang EM</searchLink>; Department of Respiratory Care, Shin Kong Wu Ho-Su Memorial Hospital, Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tang+CH%22">Tang CH</searchLink>; Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan; Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CY%22">Lin CY</searchLink>; Translational Medicine Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan. Electronic address: T016406@ms.skh.org.tw.
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  Data: <searchLink fieldCode="JN" term="%220101032%22">Biochemical pharmacology</searchLink> [Biochem Pharmacol] 2026 Sep; Vol. 251 (Pt 2), pp. 118189. <i>Date of Electronic Publication: </i>2026 Jun 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0101032 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-2968 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200062952%22">00062952 </searchLink><i>NLM ISO Abbreviation: </i>Biochem Pharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bcp.2026.118189
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        Text: English
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      – TitleFull: WISP-3 drives LUAD metastasis by suppressing miR-5004-5p to upregulate MMP-12.
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              M: 09
              Text: 2026 Sep
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              Y: 2026
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