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TWIK-1 plays distinct roles in spinal and peripheral sensory circuits controlling mechanical sensitivity and neuropathic hypersensitivity.

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Title: TWIK-1 plays distinct roles in spinal and peripheral sensory circuits controlling mechanical sensitivity and neuropathic hypersensitivity.
Authors: Yang SY; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.; Convergence Research Advanced Centre for Olfaction, DGIST, Daegu, 42988, Republic of Korea., Yun T; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea., Lee Y; Department of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea., Jeon JH; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea., Kim S; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.; Convergence Research Advanced Centre for Olfaction, DGIST, Daegu, 42988, Republic of Korea., Lim EY; Food Functionality Research Division, Korea Food Research Institute, Wanju-gun, 55365, Republic of Korea, Jeollabuk-do., Park J; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea., Kim YG; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea., Jung J; Food Functionality Research Division, Korea Food Research Institute, Wanju-gun, 55365, Republic of Korea, Jeollabuk-do., Woo JN; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea., Zhang Y; Department of Endodontics, School of Dentistry, University of Alabama at Birmingham, Birmingham, 35233, AL, USA., Son H; Department of Endodontics, School of Dentistry, University of Alabama at Birmingham, Birmingham, 35233, AL, USA., Shannonhouse J; Department of Endodontics, School of Dentistry, University of Alabama at Birmingham, Birmingham, 35233, AL, USA., Kim J; School of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul, 02841, Republic of Korea., Cho E; Metropolitan Seoul Center, Korea Basic Science Institute, Korea University, Seoul, 02841, Republic of Korea., Sung YH; Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea., Hwang EM; Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea., Suh BC; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea., Park P; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea., Song MR; Department of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea., Baek M; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea., Lee J; Food Functionality Research Division, Korea Food Research Institute, Wanju-gun, 55365, Republic of Korea, Jeollabuk-do., Kim YS; Department of Endodontics, School of Dentistry, University of Alabama at Birmingham, Birmingham, 35233, AL, USA. ykim28@uab.edu.; Department of Endodontics, University of Alabama at Birmingham, Birmingham, 35233, AL, USA. ykim28@uab.edu., Park JY; School of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul, 02841, Republic of Korea. jaeyong68@korea.ac.kr., Lee H; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea. hyosang22@dgist.ac.kr.; Convergence Research Advanced Centre for Olfaction, DGIST, Daegu, 42988, Republic of Korea. hyosang22@dgist.ac.kr.; Korea Brain Research Institute (KBRI), Daegu, 41062, Republic of Korea. hyosang22@dgist.ac.kr.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 25; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
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  Data: TWIK-1 plays distinct roles in spinal and peripheral sensory circuits controlling mechanical sensitivity and neuropathic hypersensitivity.
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  Data: <searchLink fieldCode="AU" term="%22Yang+SY%22">Yang SY</searchLink>; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.; Convergence Research Advanced Centre for Olfaction, DGIST, Daegu, 42988, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yun+T%22">Yun T</searchLink>; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+Y%22">Lee Y</searchLink>; Department of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jeon+JH%22">Jeon JH</searchLink>; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.; Convergence Research Advanced Centre for Olfaction, DGIST, Daegu, 42988, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lim+EY%22">Lim EY</searchLink>; Food Functionality Research Division, Korea Food Research Institute, Wanju-gun, 55365, Republic of Korea, Jeollabuk-do.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+YG%22">Kim YG</searchLink>; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jung+J%22">Jung J</searchLink>; Food Functionality Research Division, Korea Food Research Institute, Wanju-gun, 55365, Republic of Korea, Jeollabuk-do.<br /><searchLink fieldCode="AU" term="%22Woo+JN%22">Woo JN</searchLink>; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Endodontics, School of Dentistry, University of Alabama at Birmingham, Birmingham, 35233, AL, USA.<br /><searchLink fieldCode="AU" term="%22Son+H%22">Son H</searchLink>; Department of Endodontics, School of Dentistry, University of Alabama at Birmingham, Birmingham, 35233, AL, USA.<br /><searchLink fieldCode="AU" term="%22Shannonhouse+J%22">Shannonhouse J</searchLink>; Department of Endodontics, School of Dentistry, University of Alabama at Birmingham, Birmingham, 35233, AL, USA.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; School of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul, 02841, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cho+E%22">Cho E</searchLink>; Metropolitan Seoul Center, Korea Basic Science Institute, Korea University, Seoul, 02841, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Sung+YH%22">Sung YH</searchLink>; Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hwang+EM%22">Hwang EM</searchLink>; Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Suh+BC%22">Suh BC</searchLink>; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+P%22">Park P</searchLink>; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Song+MR%22">Song MR</searchLink>; Department of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Baek+M%22">Baek M</searchLink>; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Food Functionality Research Division, Korea Food Research Institute, Wanju-gun, 55365, Republic of Korea, Jeollabuk-do.<br /><searchLink fieldCode="AU" term="%22Kim+YS%22">Kim YS</searchLink>; Department of Endodontics, School of Dentistry, University of Alabama at Birmingham, Birmingham, 35233, AL, USA. ykim28@uab.edu.; Department of Endodontics, University of Alabama at Birmingham, Birmingham, 35233, AL, USA. ykim28@uab.edu.<br /><searchLink fieldCode="AU" term="%22Park+JY%22">Park JY</searchLink>; School of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul, 02841, Republic of Korea. jaeyong68@korea.ac.kr.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea. hyosang22@dgist.ac.kr.; Convergence Research Advanced Centre for Olfaction, DGIST, Daegu, 42988, Republic of Korea. hyosang22@dgist.ac.kr.; Korea Brain Research Institute (KBRI), Daegu, 41062, Republic of Korea. hyosang22@dgist.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%22101676423%22">Signal transduction and targeted therapy</searchLink> [Signal Transduct Target Ther] 2026 Jun 25; Vol. 11 (1). <i>Date of Electronic Publication: </i>2026 Jun 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101676423 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-3635 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220593635%22">20593635 </searchLink><i>NLM ISO Abbreviation: </i>Signal Transduct Target Ther <i>Subsets: </i>MEDLINE
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