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Individualised progesterone receptor modulator prevention strategies for triple-negative breast cancer in BRCA1 pathogenic variant carriers.

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Title: Individualised progesterone receptor modulator prevention strategies for triple-negative breast cancer in BRCA1 pathogenic variant carriers.
Authors: Widschwendter M; The Daffodil Centre, Cancer Council New South Wales and University of Sydney, Sydney, Australia. Martin.Widschwendter@sydney.edu.au.; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria. Martin.Widschwendter@sydney.edu.au.; Institute for Biomedical Ageing Research, Universität Innsbruck, Innsbruck, Austria. Martin.Widschwendter@sydney.edu.au.; Tirol Kliniken, Hall in Tirol, Austria. Martin.Widschwendter@sydney.edu.au.; Department for Women's Health, University College London, London, UK. Martin.Widschwendter@sydney.edu.au.; Department for Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. Martin.Widschwendter@sydney.edu.au., Schmutzler R; Centre for Hereditary Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO), Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany., Pashayan N; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Wesseling J; Division of Molecular Pathology and Department of Pathology, Netherlands Cancer Institute, Amsterdam & Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Tischkowitz M; Department of Genomic Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK., Zikan M; Department of Gynecology and Obstetrics, Bulovka University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic., Steenbeek M; Department of Obstetrics and Gynecology, Radboud University Medical Centre, Nijmegen, The Netherlands., Gabrielson M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Singer CF; Department of Obstetrics and Gynaecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Brisken C; ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland.; Division of Breast Cancer Research, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Gomperts R; Women on Waves, Amsterdam, Netherlands., Cameron S; Chalmers Centre for Sexual and Reproductive Health, NHS Lothian, Edinburgh, UK.; Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Evans DG; University of Manchester, School of Biological Sciences, Division of Evolution, Infection and Genomics, Manchester, Greater, Manchester, UK., Papakonstantinou A; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Department of Breast Cancer, Endocrine Tumours, and Sarcoma, Karolinska Comprehensive Cancer Center, Stockholm, Sweden., Buyse M; IDDI (International Drug Development Institute), Louvain-la-Neuve, Belgium; I-BioStat, Hasselt University, Hasselt, Belgium., Rhiem K; Centre for Hereditary Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO), Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany., Krajc M; Cancer Genetics Clinic, Institute of Oncology Ljubljana, Zaloška 2, 1000 Ljubljana, Slovenia; University of Ljubljana, Kongresni trg, Ljubljana, Slovenia., Vavourakis C; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.; Institute for Biomedical Ageing Research, Universität Innsbruck, Innsbruck, Austria., Redl E; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.; Institute for Biomedical Ageing Research, Universität Innsbruck, Innsbruck, Austria., Herzog C; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.; Institute for Biomedical Ageing Research, Universität Innsbruck, Innsbruck, Austria., Barrett J; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.; Institute for Biomedical Ageing Research, Universität Innsbruck, Innsbruck, Austria., Rasul MF; Department for Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Department of Pharmaceutical Basic Science, Faculty of Pharmacy, Tishk International University, Erbil, Iraq., Utjés D; Department for Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Papaikonomou K; Department for Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Rådestad AF; Department for Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Department of Hereditary Cancer, Theme Cancer, Karolinska Comprehensive Cancer Center, Stockholm, Sweden., Zouzos A; Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden., Alkasalias T; Department for Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; General Directorate of Scientific Research Center, Salahaddin University-Erbil, Erbil, Iraq., Gemzell-Danielsson K; Department for Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; WHO Collaborating Centre, Division of Gynecology and Reproduction, Karolinska University Hospital, Stockholm, Sweden.
Source: NPJ breast cancer [NPJ Breast Cancer] 2026 Jun 25. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article; Review
Journal Info: Publisher: Breast Cancer Research Foundation Country of Publication: United States NLM ID: 101674891 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2374-4677 (Print) Linking ISSN: 23744677 NLM ISO Abbreviation: NPJ Breast Cancer
Database: MEDLINE Ultimate
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  Data: Individualised progesterone receptor modulator prevention strategies for triple-negative breast cancer in BRCA1 pathogenic variant carriers.
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  Data: <searchLink fieldCode="AU" term="%22Widschwendter+M%22">Widschwendter M</searchLink>; The Daffodil Centre, Cancer Council New South Wales and University of Sydney, Sydney, Australia. Martin.Widschwendter@sydney.edu.au.; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria. Martin.Widschwendter@sydney.edu.au.; Institute for Biomedical Ageing Research, Universität Innsbruck, Innsbruck, Austria. Martin.Widschwendter@sydney.edu.au.; Tirol Kliniken, Hall in Tirol, Austria. Martin.Widschwendter@sydney.edu.au.; Department for Women's Health, University College London, London, UK. Martin.Widschwendter@sydney.edu.au.; Department for Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. Martin.Widschwendter@sydney.edu.au.<br /><searchLink fieldCode="AU" term="%22Schmutzler+R%22">Schmutzler R</searchLink>; Centre for Hereditary Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO), Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Pashayan+N%22">Pashayan N</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wesseling+J%22">Wesseling J</searchLink>; Division of Molecular Pathology and Department of Pathology, Netherlands Cancer Institute, Amsterdam & Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Tischkowitz+M%22">Tischkowitz M</searchLink>; Department of Genomic Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Zikan+M%22">Zikan M</searchLink>; Department of Gynecology and Obstetrics, Bulovka University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Steenbeek+M%22">Steenbeek M</searchLink>; Department of Obstetrics and Gynecology, Radboud University Medical Centre, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gabrielson+M%22">Gabrielson M</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Singer+CF%22">Singer CF</searchLink>; Department of Obstetrics and Gynaecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Brisken+C%22">Brisken C</searchLink>; ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland.; Division of Breast Cancer Research, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Gomperts+R%22">Gomperts R</searchLink>; Women on Waves, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Cameron+S%22">Cameron S</searchLink>; Chalmers Centre for Sexual and Reproductive Health, NHS Lothian, Edinburgh, UK.; Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Evans+DG%22">Evans DG</searchLink>; University of Manchester, School of Biological Sciences, Division of Evolution, Infection and Genomics, Manchester, Greater, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Papakonstantinou+A%22">Papakonstantinou A</searchLink>; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Department of Breast Cancer, Endocrine Tumours, and Sarcoma, Karolinska Comprehensive Cancer Center, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Buyse+M%22">Buyse M</searchLink>; IDDI (International Drug Development Institute), Louvain-la-Neuve, Belgium; I-BioStat, Hasselt University, Hasselt, Belgium.<br /><searchLink fieldCode="AU" term="%22Rhiem+K%22">Rhiem K</searchLink>; Centre for Hereditary Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO), Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Krajc+M%22">Krajc M</searchLink>; Cancer Genetics Clinic, Institute of Oncology Ljubljana, Zaloška 2, 1000 Ljubljana, Slovenia; University of Ljubljana, Kongresni trg, Ljubljana, Slovenia.<br /><searchLink fieldCode="AU" term="%22Vavourakis+C%22">Vavourakis C</searchLink>; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.; Institute for Biomedical Ageing Research, Universität Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Redl+E%22">Redl E</searchLink>; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.; Institute for Biomedical Ageing Research, Universität Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Herzog+C%22">Herzog C</searchLink>; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.; Institute for Biomedical Ageing Research, Universität Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Barrett+J%22">Barrett J</searchLink>; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.; Institute for Biomedical Ageing Research, Universität Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Rasul+MF%22">Rasul MF</searchLink>; Department for Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Department of Pharmaceutical Basic Science, Faculty of Pharmacy, Tishk International University, Erbil, Iraq.<br /><searchLink fieldCode="AU" term="%22Utjés+D%22">Utjés D</searchLink>; Department for Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Papaikonomou+K%22">Papaikonomou K</searchLink>; Department for Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Rådestad+AF%22">Rådestad AF</searchLink>; Department for Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Department of Hereditary Cancer, Theme Cancer, Karolinska Comprehensive Cancer Center, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Zouzos+A%22">Zouzos A</searchLink>; Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Alkasalias+T%22">Alkasalias T</searchLink>; Department for Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; General Directorate of Scientific Research Center, Salahaddin University-Erbil, Erbil, Iraq.<br /><searchLink fieldCode="AU" term="%22Gemzell-Danielsson+K%22">Gemzell-Danielsson K</searchLink>; Department for Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; WHO Collaborating Centre, Division of Gynecology and Reproduction, Karolinska University Hospital, Stockholm, Sweden.
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