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Base editing reveals an essential role for NANOG in human embryogenesis.

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Title: Base editing reveals an essential role for NANOG in human embryogenesis.
Authors: Bower OJ; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, London, UK., R Orsi AE; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., McMahon R; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Staneva D; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Blagrove J; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Singh K; MRC Laboratory of Molecular Biology, Cambridge, UK., Simon CS; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., McCarthy A; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, London, UK., Garcia P; Assisted Reproduction and Gynaecology Centre, London, UK., Shaikly V; Assisted Reproduction and Gynaecology Centre, London, UK., Taranissi M; Assisted Reproduction and Gynaecology Centre, London, UK., Wilding M; Create Fertility, London, UK., Serhal P; Centre for Reproductive and Genetic Health, London, United Kingdom., Odia RA; Centre for Reproductive and Genetic Health, London, United Kingdom., Vasilic M; Centre for Reproductive and Genetic Health, London, United Kingdom., Choudhary M; Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK., Papathanasiou A; Bourn Hall Clinic, Bourn, UK., Elder K; Bourn Hall Clinic, Bourn, UK., Snell P; Bourn Hall Clinic, Bourn, UK., Christie L; Bourn Hall Clinic, Bourn, UK., Arbab M; Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hosptial, Harvard Medical School, Boston, MA, USA.; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Herbert M; Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK.; Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia., Harasimov K; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. kh767@cam.ac.uk.; Sidney Sussex College, Cambridge, UK. kh767@cam.ac.uk., Niakan KK; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. kkn21@cam.ac.uk.; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, London, UK. kkn21@cam.ac.uk.; Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, UK. kkn21@cam.ac.uk.; Epigenetics Programme, Babraham Institute, Cambridge, UK. kkn21@cam.ac.uk.
Source: Nature [Nature] 2026 Jun 25. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Base editing reveals an essential role for NANOG in human embryogenesis.
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  Data: <searchLink fieldCode="AU" term="%22Bower+OJ%22">Bower OJ</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22R+Orsi+AE%22">R Orsi AE</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22McMahon+R%22">McMahon R</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Staneva+D%22">Staneva D</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Blagrove+J%22">Blagrove J</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Singh+K%22">Singh K</searchLink>; MRC Laboratory of Molecular Biology, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Simon+CS%22">Simon CS</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22McCarthy+A%22">McCarthy A</searchLink>; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Garcia+P%22">Garcia P</searchLink>; Assisted Reproduction and Gynaecology Centre, London, UK.<br /><searchLink fieldCode="AU" term="%22Shaikly+V%22">Shaikly V</searchLink>; Assisted Reproduction and Gynaecology Centre, London, UK.<br /><searchLink fieldCode="AU" term="%22Taranissi+M%22">Taranissi M</searchLink>; Assisted Reproduction and Gynaecology Centre, London, UK.<br /><searchLink fieldCode="AU" term="%22Wilding+M%22">Wilding M</searchLink>; Create Fertility, London, UK.<br /><searchLink fieldCode="AU" term="%22Serhal+P%22">Serhal P</searchLink>; Centre for Reproductive and Genetic Health, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Odia+RA%22">Odia RA</searchLink>; Centre for Reproductive and Genetic Health, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Vasilic+M%22">Vasilic M</searchLink>; Centre for Reproductive and Genetic Health, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Choudhary+M%22">Choudhary M</searchLink>; Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Papathanasiou+A%22">Papathanasiou A</searchLink>; Bourn Hall Clinic, Bourn, UK.<br /><searchLink fieldCode="AU" term="%22Elder+K%22">Elder K</searchLink>; Bourn Hall Clinic, Bourn, UK.<br /><searchLink fieldCode="AU" term="%22Snell+P%22">Snell P</searchLink>; Bourn Hall Clinic, Bourn, UK.<br /><searchLink fieldCode="AU" term="%22Christie+L%22">Christie L</searchLink>; Bourn Hall Clinic, Bourn, UK.<br /><searchLink fieldCode="AU" term="%22Arbab+M%22">Arbab M</searchLink>; Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hosptial, Harvard Medical School, Boston, MA, USA.; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+DR%22">Liu DR</searchLink>; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Herbert+M%22">Herbert M</searchLink>; Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK.; Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Harasimov+K%22">Harasimov K</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. kh767@cam.ac.uk.; Sidney Sussex College, Cambridge, UK. kh767@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Niakan+KK%22">Niakan KK</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. kkn21@cam.ac.uk.; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, London, UK. kkn21@cam.ac.uk.; Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, UK. kkn21@cam.ac.uk.; Epigenetics Programme, Babraham Institute, Cambridge, UK. kkn21@cam.ac.uk.
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