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Selective histone deacetylase inhibition as a therapeutically relevant strategy in H3K27M-glioma.

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Title: Selective histone deacetylase inhibition as a therapeutically relevant strategy in H3K27M-glioma.
Authors: Groves A; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Division of Hematology/Oncology, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA., Kirkland OO; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Department of Chemistry & Chemical Biology, Harvard University, Cambridge, Massachusetts, USA., Cascio CL; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Wang X; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Heaslip C; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Marques JG; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Song C; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Poetschke R; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Wang T; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Chin DH; Department of Genetics and Genome Sciences, Case Western University School of Medicine, Cleveland, Ohio, USA., Asante Y; Department of Genetics and Genome Sciences, Case Western University School of Medicine, Cleveland, Ohio, USA., Liu Q; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Kim H; Department of Genetics and Genome Sciences, Case Western University School of Medicine, Cleveland, Ohio, USA., Gu S; Department of Genetics and Genome Sciences, Case Western University School of Medicine, Cleveland, Ohio, USA., Trissal M; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Labelle J; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Cruzeiro GAV; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Jones KL; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Cameron AB; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Clark LM; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Leeper B; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Nguyen QD; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Gryder BE; Department of Genetics and Genome Sciences, Case Western University School of Medicine, Cleveland, Ohio, USA., Filbin MG; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Qi J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Source: Neuro-oncology [Neuro Oncol] 2026 Jun 25. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Groves+A%22">Groves A</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Division of Hematology/Oncology, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.<br /><searchLink fieldCode="AU" term="%22Kirkland+OO%22">Kirkland OO</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Department of Chemistry & Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Cascio+CL%22">Cascio CL</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Heaslip+C%22">Heaslip C</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Marques+JG%22">Marques JG</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Song+C%22">Song C</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Poetschke+R%22">Poetschke R</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; 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Department of Genetics and Genome Sciences, Case Western University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Trissal+M%22">Trissal M</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Labelle+J%22">Labelle J</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Cruzeiro+GAV%22">Cruzeiro GAV</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Jones+KL%22">Jones KL</searchLink>; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Cameron+AB%22">Cameron AB</searchLink>; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Clark+LM%22">Clark LM</searchLink>; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Leeper+B%22">Leeper B</searchLink>; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+QD%22">Nguyen QD</searchLink>; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Gryder+BE%22">Gryder BE</searchLink>; Department of Genetics and Genome Sciences, Case Western University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Filbin+MG%22">Filbin MG</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Qi+J%22">Qi J</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
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