Discovery of Rhubarb Anthraquinones Physcion and Rhein as Functional Inhibitors of TRPV1 Against Lipopolysaccharide-Induced Neuroinflammation.

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Title: Discovery of Rhubarb Anthraquinones Physcion and Rhein as Functional Inhibitors of TRPV1 Against Lipopolysaccharide-Induced Neuroinflammation.
Authors: Li S; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, China., He Y; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; School of Bioengineering, Sichuan University of Science and Engineering, Yibin 644000, China., Kam H; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China., Chen H; Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, Department of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China., Bian JS; Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, Department of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China., Xu N; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, China.; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China., Gong G; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; PolyU-BGI Joint Research Centre for Genomics and Synthetic Biology in Global Ocean Resources, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, China., Liao Q; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; PolyU-BGI Joint Research Centre for Genomics and Synthetic Biology in Global Ocean Resources, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, China., Zhao C; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; PolyU-BGI Joint Research Centre for Genomics and Synthetic Biology in Global Ocean Resources, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, China., Yang B; Nutrilite Health Institute, Amway (Shanghai) Innovation & Science Co., Ltd., Shanghai 201203, China., Chen L; Nutrilite Health Institute, Amway (Shanghai) Innovation & Science Co., Ltd., Shanghai 201203, China., Kuok KI; Crystal Vision Biotechnology Limited, Taipa, Macao 999078, China., Lee SMY; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, China.; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; PolyU-BGI Joint Research Centre for Genomics and Synthetic Biology in Global Ocean Resources, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, China.
Source: Molecules (Basel, Switzerland) [Molecules] 2026 Jun 11; Vol. 31 (12). Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1420-3049
DOI:10.3390/molecules31122049