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Discovery of Rhubarb Anthraquinones Physcion and Rhein as Functional Inhibitors of TRPV1 Against Lipopolysaccharide-Induced Neuroinflammation.

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Title: Discovery of Rhubarb Anthraquinones Physcion and Rhein as Functional Inhibitors of TRPV1 Against Lipopolysaccharide-Induced Neuroinflammation.
Authors: Li S; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, China., He Y; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; School of Bioengineering, Sichuan University of Science and Engineering, Yibin 644000, China., Kam H; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China., Chen H; Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, Department of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China., Bian JS; Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, Department of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China., Xu N; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, China.; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China., Gong G; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; PolyU-BGI Joint Research Centre for Genomics and Synthetic Biology in Global Ocean Resources, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, China., Liao Q; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; PolyU-BGI Joint Research Centre for Genomics and Synthetic Biology in Global Ocean Resources, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, China., Zhao C; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; PolyU-BGI Joint Research Centre for Genomics and Synthetic Biology in Global Ocean Resources, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, China., Yang B; Nutrilite Health Institute, Amway (Shanghai) Innovation & Science Co., Ltd., Shanghai 201203, China., Chen L; Nutrilite Health Institute, Amway (Shanghai) Innovation & Science Co., Ltd., Shanghai 201203, China., Kuok KI; Crystal Vision Biotechnology Limited, Taipa, Macao 999078, China., Lee SMY; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, China.; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; PolyU-BGI Joint Research Centre for Genomics and Synthetic Biology in Global Ocean Resources, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, China.
Source: Molecules (Basel, Switzerland) [Molecules] 2026 Jun 11; Vol. 31 (12). Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of Rhubarb Anthraquinones Physcion and Rhein as Functional Inhibitors of TRPV1 Against Lipopolysaccharide-Induced Neuroinflammation.
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  Data: <searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; School of Bioengineering, Sichuan University of Science and Engineering, Yibin 644000, China.<br /><searchLink fieldCode="AU" term="%22Kam+H%22">Kam H</searchLink>; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, Department of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.<br /><searchLink fieldCode="AU" term="%22Bian+JS%22">Bian JS</searchLink>; Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, Department of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.<br /><searchLink fieldCode="AU" term="%22Xu+N%22">Xu N</searchLink>; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, China.; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Gong+G%22">Gong G</searchLink>; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; PolyU-BGI Joint Research Centre for Genomics and Synthetic Biology in Global Ocean Resources, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Liao+Q%22">Liao Q</searchLink>; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; PolyU-BGI Joint Research Centre for Genomics and Synthetic Biology in Global Ocean Resources, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Zhao+C%22">Zhao C</searchLink>; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; PolyU-BGI Joint Research Centre for Genomics and Synthetic Biology in Global Ocean Resources, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Yang+B%22">Yang B</searchLink>; Nutrilite Health Institute, Amway (Shanghai) Innovation & Science Co., Ltd., Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Nutrilite Health Institute, Amway (Shanghai) Innovation & Science Co., Ltd., Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Kuok+KI%22">Kuok KI</searchLink>; Crystal Vision Biotechnology Limited, Taipa, Macao 999078, China.<br /><searchLink fieldCode="AU" term="%22Lee+SMY%22">Lee SMY</searchLink>; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, China.; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.; PolyU-BGI Joint Research Centre for Genomics and Synthetic Biology in Global Ocean Resources, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, China.
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  Data: <searchLink fieldCode="JN" term="%22100964009%22">Molecules (Basel, Switzerland)</searchLink> [Molecules] 2026 Jun 11; Vol. 31 (12). <i>Date of Electronic Publication: </i>2026 Jun 11.
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        Value: 10.3390/molecules31122049
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        Text: English
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      – TitleFull: Discovery of Rhubarb Anthraquinones Physcion and Rhein as Functional Inhibitors of TRPV1 Against Lipopolysaccharide-Induced Neuroinflammation.
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              Text: 2026 Jun 11
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