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Safety and Efficacy of Once-Daily Oral Paltusotine in Acromegaly: ACROBAT Advance Open-Label Extension Up to 4 Years.

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Title: Safety and Efficacy of Once-Daily Oral Paltusotine in Acromegaly: ACROBAT Advance Open-Label Extension Up to 4 Years.
Authors: Gadelha MR; Neuroendocrinology Research Center/Endocrinology Division, Medical School and Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, CEP 21941-913, Brazil.; Clinical Research Center, Instituto Estadual do Cérebro Paulo Niemeyer, State Department of Health, Rio de Janeiro, CEP 20231-092, Brazil., Gordon MB; Allegheny Neuroendocrinology Center, Division of Endocrinology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA., Doknic M; Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia., Mezősi E; First Department of Internal Medicine, Faculty of Medicine, University of Pécs Medical School, Pécs 7624, Hungary., Tóth M; Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, Budapest 1085, Hungary., Randeva H; Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK.; Division of Biomedicine, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK., Boguszewski CL; Department of Internal Medicine, Endocrine Division (SEMPR), Federal University of Paraná, Curitiba 80030-110, Brazil., Davidson C; Crinetics Pharmaceuticals Inc, San Diego, California 92121, USA., Casagrande A; Crinetics Pharmaceuticals Inc, San Diego, California 92121, USA., Jochelson T; Crinetics Pharmaceuticals Inc, San Diego, California 92121, USA., Krasner A; Crinetics Pharmaceuticals Inc, San Diego, California 92121, USA.
Source: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2026 Jun 26. Date of Electronic Publication: 2026 Jun 26.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE
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  Data: Safety and Efficacy of Once-Daily Oral Paltusotine in Acromegaly: ACROBAT Advance Open-Label Extension Up to 4 Years.
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  Data: <searchLink fieldCode="AU" term="%22Gadelha+MR%22">Gadelha MR</searchLink>; Neuroendocrinology Research Center/Endocrinology Division, Medical School and Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, CEP 21941-913, Brazil.; Clinical Research Center, Instituto Estadual do Cérebro Paulo Niemeyer, State Department of Health, Rio de Janeiro, CEP 20231-092, Brazil.<br /><searchLink fieldCode="AU" term="%22Gordon+MB%22">Gordon MB</searchLink>; Allegheny Neuroendocrinology Center, Division of Endocrinology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA.<br /><searchLink fieldCode="AU" term="%22Doknic+M%22">Doknic M</searchLink>; Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia.<br /><searchLink fieldCode="AU" term="%22Mezősi+E%22">Mezősi E</searchLink>; First Department of Internal Medicine, Faculty of Medicine, University of Pécs Medical School, Pécs 7624, Hungary.<br /><searchLink fieldCode="AU" term="%22Tóth+M%22">Tóth M</searchLink>; Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, Budapest 1085, Hungary.<br /><searchLink fieldCode="AU" term="%22Randeva+H%22">Randeva H</searchLink>; Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK.; Division of Biomedicine, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.<br /><searchLink fieldCode="AU" term="%22Boguszewski+CL%22">Boguszewski CL</searchLink>; Department of Internal Medicine, Endocrine Division (SEMPR), Federal University of Paraná, Curitiba 80030-110, Brazil.<br /><searchLink fieldCode="AU" term="%22Davidson+C%22">Davidson C</searchLink>; Crinetics Pharmaceuticals Inc, San Diego, California 92121, USA.<br /><searchLink fieldCode="AU" term="%22Casagrande+A%22">Casagrande A</searchLink>; Crinetics Pharmaceuticals Inc, San Diego, California 92121, USA.<br /><searchLink fieldCode="AU" term="%22Jochelson+T%22">Jochelson T</searchLink>; Crinetics Pharmaceuticals Inc, San Diego, California 92121, USA.<br /><searchLink fieldCode="AU" term="%22Krasner+A%22">Krasner A</searchLink>; Crinetics Pharmaceuticals Inc, San Diego, California 92121, USA.
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              Text: 2026 Jun 26
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