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Early Detriment Analysis of First-Line Nivolumab plus Ipilimumab-Based Therapy in Patients with Metastatic Non-Small Cell Lung Cancer.

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Title: Early Detriment Analysis of First-Line Nivolumab plus Ipilimumab-Based Therapy in Patients with Metastatic Non-Small Cell Lung Cancer.
Authors: Borghaei H; Hematology and Oncology Department, Fox Chase Cancer Center, Temple Health, Philadelphia, Pennsylvania., Balli D; Informatics and Predictive Sciences, Bristol Myers Squibb, Princeton, New Jersey., Paz-Ares LG; Medical Oncology Department, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain., Reck M; Department of Thoracic Oncology, Airway Research Center North, German Center for Lung Research, LungenClinic Grosshansdorf, Grosshansdorf, Germany., Lu S; Department of Medical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China., Ramalingam SS; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia., Brahmer JR; Department of Oncology, The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland., John T; Medical Oncology Department, Austin Hospital, Heidelberg, Australia., Carbone DP; Department of Medical Oncology, The Ohio State University Comprehensive Cancer Center and the Pelotonia Institute for Immuno-Oncology, Columbus, Ohio., Ciuleanu TE; Department of Medical Oncology, Institutul Oncologic Prof. Dr. Ion Chiricuta, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania., Schenker M; Department of Medical Oncology, Sf Nectarie Oncology Center, University of Medicine and Pharmacy of Craiova, Craiova, Romania., Cobo M; Department of Medical Oncology, Unidad de Gestión Clínica Intercentros de Oncología Médica, Hospitales Universitarios Regional y Virgen de la Victoria, Malaga, Spain., Zurawski B; Chemotherapy Department, Ambulatorium Chemioterapii, Bydgoszcz, Poland., Pluzanski A; Department of Lung Cancer and Chest Tumours, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Lee JS; Department of Hematology/Oncology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Agrawal S; Global Drug Development, Bristol Myers Squibb, Princeton, New Jersey., Spires T; Translational Medicine, Bristol Myers Squibb, Princeton, New Jersey., Neely J; Translational Medicine, Bristol Myers Squibb, Princeton, New Jersey., Ip V; Global Medical Oncology, Bristol Myers Squibb, Princeton, New Jersey., Eccles LJ; Global Medical Oncology, Bristol Myers Squibb, Princeton, New Jersey., Chang H; Informatics and Predictive Sciences, Bristol Myers Squibb, Princeton, New Jersey., Szustakowski JD; Translational Bioinformatics, Bristol Myers Squibb, Princeton, New Jersey., Bhatia S; Global Medical Oncology, Bristol Myers Squibb, Princeton, New Jersey., Yadav A; Data Science, Bristol Myers Squibb, Princeton, New Jersey., Eddy N; Data Science, Bristol Myers Squibb, Princeton, New Jersey., Geese WJ; Translational Medicine, Bristol Myers Squibb, Princeton, New Jersey., O'Byrne KJ; Department of Medical Oncology, Princess Alexandra Hospital, Translational Research Institute and Queensland University of Technology, Brisbane, Australia.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2026 Jun 26, pp. OF1-OF14. Date of Electronic Publication: 2026 Jun 26.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
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  Data: Early Detriment Analysis of First-Line Nivolumab plus Ipilimumab-Based Therapy in Patients with Metastatic Non-Small Cell Lung Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Borghaei+H%22">Borghaei H</searchLink>; Hematology and Oncology Department, Fox Chase Cancer Center, Temple Health, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Balli+D%22">Balli D</searchLink>; Informatics and Predictive Sciences, Bristol Myers Squibb, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Paz-Ares+LG%22">Paz-Ares LG</searchLink>; Medical Oncology Department, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Reck+M%22">Reck M</searchLink>; Department of Thoracic Oncology, Airway Research Center North, German Center for Lung Research, LungenClinic Grosshansdorf, Grosshansdorf, Germany.<br /><searchLink fieldCode="AU" term="%22Lu+S%22">Lu S</searchLink>; Department of Medical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Ramalingam+SS%22">Ramalingam SS</searchLink>; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Brahmer+JR%22">Brahmer JR</searchLink>; Department of Oncology, The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22John+T%22">John T</searchLink>; Medical Oncology Department, Austin Hospital, Heidelberg, Australia.<br /><searchLink fieldCode="AU" term="%22Carbone+DP%22">Carbone DP</searchLink>; Department of Medical Oncology, The Ohio State University Comprehensive Cancer Center and the Pelotonia Institute for Immuno-Oncology, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Ciuleanu+TE%22">Ciuleanu TE</searchLink>; Department of Medical Oncology, Institutul Oncologic Prof. Dr. Ion Chiricuta, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania.<br /><searchLink fieldCode="AU" term="%22Schenker+M%22">Schenker M</searchLink>; Department of Medical Oncology, Sf Nectarie Oncology Center, University of Medicine and Pharmacy of Craiova, Craiova, Romania.<br /><searchLink fieldCode="AU" term="%22Cobo+M%22">Cobo M</searchLink>; Department of Medical Oncology, Unidad de Gestión Clínica Intercentros de Oncología Médica, Hospitales Universitarios Regional y Virgen de la Victoria, Malaga, Spain.<br /><searchLink fieldCode="AU" term="%22Zurawski+B%22">Zurawski B</searchLink>; Chemotherapy Department, Ambulatorium Chemioterapii, Bydgoszcz, Poland.<br /><searchLink fieldCode="AU" term="%22Pluzanski+A%22">Pluzanski A</searchLink>; Department of Lung Cancer and Chest Tumours, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Lee+JS%22">Lee JS</searchLink>; Department of Hematology/Oncology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Agrawal+S%22">Agrawal S</searchLink>; Global Drug Development, Bristol Myers Squibb, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Spires+T%22">Spires T</searchLink>; Translational Medicine, Bristol Myers Squibb, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Neely+J%22">Neely J</searchLink>; Translational Medicine, Bristol Myers Squibb, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Ip+V%22">Ip V</searchLink>; Global Medical Oncology, Bristol Myers Squibb, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Eccles+LJ%22">Eccles LJ</searchLink>; Global Medical Oncology, Bristol Myers Squibb, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Chang+H%22">Chang H</searchLink>; Informatics and Predictive Sciences, Bristol Myers Squibb, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Szustakowski+JD%22">Szustakowski JD</searchLink>; Translational Bioinformatics, Bristol Myers Squibb, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Bhatia+S%22">Bhatia S</searchLink>; Global Medical Oncology, Bristol Myers Squibb, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Yadav+A%22">Yadav A</searchLink>; Data Science, Bristol Myers Squibb, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Eddy+N%22">Eddy N</searchLink>; Data Science, Bristol Myers Squibb, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Geese+WJ%22">Geese WJ</searchLink>; Translational Medicine, Bristol Myers Squibb, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22O'Byrne+KJ%22">O'Byrne KJ</searchLink>; Department of Medical Oncology, Princess Alexandra Hospital, Translational Research Institute and Queensland University of Technology, Brisbane, Australia.
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