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BCMA-directed therapy with cizutamig induces rapid improvement in long-standing systemic sclerosis-associated interstitial lung disease.

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Title: BCMA-directed therapy with cizutamig induces rapid improvement in long-standing systemic sclerosis-associated interstitial lung disease.
Authors: Phithak E; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Albach F; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Biesen R; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Dzamukova M; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Rheumatism Research Centre (DRFZ) Berlin, Leibniz Institute, Berlin, Germany., Drzeniek NM; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; BIH Centre for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States., Schleser D; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Rheumatism Research Centre (DRFZ) Berlin, Leibniz Institute, Berlin, Germany., Fiebig L; German Rheumatism Research Centre (DRFZ) Berlin, Leibniz Institute, Berlin, Germany., Wiebe E; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Fleischmann A; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Sattler A; German Rheumatism Research Centre (DRFZ) Berlin, Leibniz Institute, Berlin, Germany., Wung P; Candid Therapeutics, San Diego, CA, United States., Haddon J; Candid Therapeutics, San Diego, CA, United States., Kruger P; Candid Therapeutics, San Diego, CA, United States., Lu T; Candid Therapeutics, San Diego, CA, United States., Song K; Candid Therapeutics, San Diego, CA, United States., Probst M; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Doellinger F; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Diagnostic and Interventional Radiology and Nuclear Medicine, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Hauser AE; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Rheumatism Research Centre (DRFZ) Berlin, Leibniz Institute, Berlin, Germany., Kleyer A; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Vogel-Claussen J; Department of Radiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Witzenrath M; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Centre for Lung Research (DZL), Berlin, Germany., Alexander T; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Krönke G; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Rheumatism Research Centre (DRFZ) Berlin, Leibniz Institute, Berlin, Germany.; ImmunoPreCept Cluster, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, Allergology and Immunology, c/o Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany, Berlin., Siegert E; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Simon D; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Radiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, Allergology and Immunology, c/o Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany, Berlin.
Source: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2026 Jun 30; Vol. 65 (7).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100883501 Publication Model: Print Cited Medium: Internet ISSN: 1462-0332 (Electronic) Linking ISSN: 14620324 NLM ISO Abbreviation: Rheumatology (Oxford) Subsets: MEDLINE; In Process
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  Data: BCMA-directed therapy with cizutamig induces rapid improvement in long-standing systemic sclerosis-associated interstitial lung disease.
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  Data: <searchLink fieldCode="AU" term="%22Phithak+E%22">Phithak E</searchLink>; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Albach+F%22">Albach F</searchLink>; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Biesen+R%22">Biesen R</searchLink>; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Dzamukova+M%22">Dzamukova M</searchLink>; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Rheumatism Research Centre (DRFZ) Berlin, Leibniz Institute, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Drzeniek+NM%22">Drzeniek NM</searchLink>; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; BIH Centre for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Schleser+D%22">Schleser D</searchLink>; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Rheumatism Research Centre (DRFZ) Berlin, Leibniz Institute, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Fiebig+L%22">Fiebig L</searchLink>; German Rheumatism Research Centre (DRFZ) Berlin, Leibniz Institute, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Wiebe+E%22">Wiebe E</searchLink>; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Fleischmann+A%22">Fleischmann A</searchLink>; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sattler+A%22">Sattler A</searchLink>; German Rheumatism Research Centre (DRFZ) Berlin, Leibniz Institute, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Wung+P%22">Wung P</searchLink>; Candid Therapeutics, San Diego, CA, United States.<br /><searchLink fieldCode="AU" term="%22Haddon+J%22">Haddon J</searchLink>; Candid Therapeutics, San Diego, CA, United States.<br /><searchLink fieldCode="AU" term="%22Kruger+P%22">Kruger P</searchLink>; Candid Therapeutics, San Diego, CA, United States.<br /><searchLink fieldCode="AU" term="%22Lu+T%22">Lu T</searchLink>; Candid Therapeutics, San Diego, CA, United States.<br /><searchLink fieldCode="AU" term="%22Song+K%22">Song K</searchLink>; Candid Therapeutics, San Diego, CA, United States.<br /><searchLink fieldCode="AU" term="%22Probst+M%22">Probst M</searchLink>; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Doellinger+F%22">Doellinger F</searchLink>; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Diagnostic and Interventional Radiology and Nuclear Medicine, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hauser+AE%22">Hauser AE</searchLink>; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Rheumatism Research Centre (DRFZ) Berlin, Leibniz Institute, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kleyer+A%22">Kleyer A</searchLink>; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Vogel-Claussen+J%22">Vogel-Claussen J</searchLink>; Department of Radiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Witzenrath+M%22">Witzenrath M</searchLink>; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Centre for Lung Research (DZL), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Alexander+T%22">Alexander T</searchLink>; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Krönke+G%22">Krönke G</searchLink>; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Rheumatism Research Centre (DRFZ) Berlin, Leibniz Institute, Berlin, Germany.; ImmunoPreCept Cluster, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, Allergology and Immunology, c/o Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany, Berlin.<br /><searchLink fieldCode="AU" term="%22Siegert+E%22">Siegert E</searchLink>; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Simon+D%22">Simon D</searchLink>; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Radiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, Allergology and Immunology, c/o Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany, Berlin.
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