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Plasma GDF15 affects long-term dementia risk and alters neuroimmune signaling.

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Title: Plasma GDF15 affects long-term dementia risk and alters neuroimmune signaling.
Authors: Blew CO; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Duggan MR; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Tsitsipatis D; Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Gomez GT; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Rodriguez-Hernandez Z; Institute of Epidemiology and Prevention, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Pilling LC; Department of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK., Chen J; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Jacobsen E; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Dark HE; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Lu Y; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Drouin SM; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.; Department of Psychology, University of New Brunswick, Fredericton, New Brunswick, Canada., Joynes CM; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Yao M; Centre for Quantitative Medicine, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore., Bilgel M; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Moghekar A; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Tian Q; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Candia J; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Kaileh M; Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Gupta A; Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Mazan-Mamczarz K; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Gorospe M; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Lyashkov A; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Lukyanenko Y; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Kivimaki M; Brain Sciences, University College London, London, England, UK., Frank P; Brain Sciences, University College London, London, England, UK., Jennings LL; Novartis, Cambridge, MA, USA., Gudmundsdottir V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Launer LJ; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA., Kaneko N; NEC Solution Innovators Limited, Koto-ku, Tokyo, Japan., Kato S; NEC Solution Innovators Limited, Koto-ku, Tokyo, Japan.; FonesLife Corporation, Chuo-ku, Tokyo, Japan., Furuichi M; NEC Solution Innovators Limited, Koto-ku, Tokyo, Japan.; FonesLife Corporation, Chuo-ku, Tokyo, Japan., Shibayama M; NEC Solution Innovators Limited, Koto-ku, Tokyo, Japan.; FonesLife Corporation, Chuo-ku, Tokyo, Japan., Katsuno M; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.; Department of Clinical Research Education, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan., Hiraga K; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan., Nishita Y; Department of Epidemiology of Aging, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan., Otsuka R; Department of Epidemiology of Aging, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan., Pike JR; Optimal Aging Institute, New York University Grossman School of Medicine, New York, NY, USA., Rooney MR; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Schlosser P; Institute of Epidemiology and Prevention, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Centre for Integrative Biological Signaling Studies (CIBSS), University of Freiburg, Freiburg, Germany., Cui Y; Artificial Intelligence in Biomedical Imaging Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Erus G; Artificial Intelligence in Biomedical Imaging Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Davatzikos C; Artificial Intelligence in Biomedical Imaging Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gottesman RF; Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Waga I; NEC Solution Innovators Limited, Koto-ku, Tokyo, Japan.; FonesLife Corporation, Chuo-ku, Tokyo, Japan.; Well-being Design Institute for Health, Tohoku University, Aoba-ku, Sendai, Japan., Palta P; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ballantyne C; Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Griswold M; Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA., Liu Z; Department of Biostatistics, Columbia University, New York, NY, USA., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Herman AB; Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Walker KA; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Source: Science advances [Sci Adv] 2026 Jun 26; Vol. 12 (26), pp. eaec7614. Date of Electronic Publication: 2026 Jun 26.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Plasma GDF15 affects long-term dementia risk and alters neuroimmune signaling.
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              Value: 26
          Titles:
            – TitleFull: Science advances
              Type: main
ResultId 1