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Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities.

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Title: Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities.
Authors: Kuo HH; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Bhinder B; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA., Gokozan HN; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY USA 10065., Gorski K; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY USA 10065., Chandra P; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY USA 10065., Manohar J; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Guevara D; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Otilano J; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Moyer J; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Tranquille M; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Ackermann S; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Capuano J; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Cheung C; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Caiazza TA; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Reuben PL; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Tsomides AM; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Irizarry A; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Sigouros M; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Wilkes D; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., King A; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Kane T; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Al Assaad M; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY USA 10065., Al Zoughbi W; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY USA 10065., Ohara K; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY USA 10065., Auh J; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Waltman P; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA., Madorsky Rowdo FP; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Podaza E; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Gallegos V; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Nguyen J; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Shah R; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Shah M; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Ocean A; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Scherr D; Department of Urology, Weill Cornell Medicine, New York, NY 10065 USA., Altorki N; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY 10065 USA., Frey M; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA., Molina AM; Department of Medicine, Weill Cornell Medicine, New York, NY 10065 USA., Newman L; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Bea V; Department of Surgery, Weill Cornell Medicine, New York, NY 10065 USA.; NewYork-Presbyterian Weill Cornell Brooklyn Methodist Hospital, Brooklyn, NY 11215 USA., Chapman-Davis E; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Goncalves MD; Department of Medicine, Weill Cornell Medicine, New York, NY 10065 USA., Saxena A; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Shukla PJ; Department of Surgery, Weill Cornell Medicine, New York, NY 10065 USA., Holcomb K; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA., Simmons R; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Tagawa S; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Zippin JH; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.; Department of Dermatology, Weill Cornell Medicine, New York, NY 10021, USA., Cantillo E; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Chandwani R; Department of Surgery, Weill Cornell Medicine, New York, NY 10065 USA.; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY 10065, USA., Davis M; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Garrett K; Department of Surgery, Weill Cornell Medicine, New York, NY 10065 USA., Kasi PM; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Marti J; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Nanus D; Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY 10065 USA., Nauseef JT, Popa E; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Siddiqui MT; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY USA 10065., Alonso A; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Sternberg CN; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Faltas BM; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Elemento O; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA.; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY 10021, USA., Mosquera JM; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY USA 10065., Sboner A; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA., Martin ML; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
Source: Science advances [Sci Adv] 2026 Jun 26; Vol. 12 (26), pp. eadz3351. Date of Electronic Publication: 2026 Jun 26.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities.
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            – D: 26
              M: 06
              Text: 2026 Jun 26
              Type: published
              Y: 2026
          Identifiers:
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              Value: 2375-2548
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            – TitleFull: Science advances
              Type: main
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