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Multiomic analysis identifies glutaminolysis-dependent metabolic enhancement of immune memory utilised for vaccine development.

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Title: Multiomic analysis identifies glutaminolysis-dependent metabolic enhancement of immune memory utilised for vaccine development.
Authors: Sowerby JM; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Kotagiri P; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Clare S; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Griffiths D; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Knight O; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Cuthbertson I; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Harcourt K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Pereyra Gerber P; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Pshenichnaya I; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK., Connor C; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Denton A; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Stoll GA; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK., Matara C; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Keel C; National Institute for Health Research Cambridge Centre for Clinical Research, Cambridge, UK., Manferrari G; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Birkle T; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Naydenova P; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Peck H; WHO Collaborating Centre for Reference and Research on Influenza (VIDRL), Peter Doherty Institute for Infection and Immunity, 792 Elizabeth Street, Melbourne, Australia., Lyons PA; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Barr I; WHO Collaborating Centre for Reference and Research on Influenza (VIDRL), Peter Doherty Institute for Infection and Immunity, 792 Elizabeth Street, Melbourne, Australia., Modis Y; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK., Dougan G; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Matheson NJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.; NHS Blood and Transplant, Cambridge, UK., Smith KGC; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., McKinney EF; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK. efm30@cam.ac.uk.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK. efm30@cam.ac.uk.; Cambridge Centre for Artificial Intelligence in Medicine, Cambridge, UK. efm30@cam.ac.uk.
Source: Nature communications [Nat Commun] 2026 Jun 26. Date of Electronic Publication: 2026 Jun 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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