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The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence.

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Title: The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence.
Authors: Perez J MJ; Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France. perezm@ie-freiburg.mpg.de.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. perezm@ie-freiburg.mpg.de.; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. perezm@ie-freiburg.mpg.de., Lam A; Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France., Weissleder C; Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Bertoli F; Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Raji H; Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Bosch M; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Nemazanyy I; Platform for Metabolic Analyses, Structure Fédérative de Recherche Necker, INSERM US24/CNRS UAR 3633, Paris, France., Kalb S; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Kehili M; Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France., Hirschberg I; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Brunetti D; Department of Clinical Sciences and Community Health, Excellence Department 2023-2027, University of Milan, Milan, Italy.; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy., Heckenbach I; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark., Scheibye-Knudsen M; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark., Deleidi M; Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France. michela.deleidi@institutimagine.org.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. michela.deleidi@institutimagine.org.
Source: Nature neuroscience [Nat Neurosci] 2026 Jun 26. Date of Electronic Publication: 2026 Jun 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Perez+J+MJ%22">Perez J MJ</searchLink>; Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France. perezm@ie-freiburg.mpg.de.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. perezm@ie-freiburg.mpg.de.; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. perezm@ie-freiburg.mpg.de.<br /><searchLink fieldCode="AU" term="%22Lam+A%22">Lam A</searchLink>; Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Weissleder+C%22">Weissleder C</searchLink>; Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bertoli+F%22">Bertoli F</searchLink>; Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Raji+H%22">Raji H</searchLink>; Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bosch+M%22">Bosch M</searchLink>; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Nemazanyy+I%22">Nemazanyy I</searchLink>; Platform for Metabolic Analyses, Structure Fédérative de Recherche Necker, INSERM US24/CNRS UAR 3633, Paris, France.<br /><searchLink fieldCode="AU" term="%22Kalb+S%22">Kalb S</searchLink>; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kehili+M%22">Kehili M</searchLink>; Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Hirschberg+I%22">Hirschberg I</searchLink>; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Brunetti+D%22">Brunetti D</searchLink>; Department of Clinical Sciences and Community Health, Excellence Department 2023-2027, University of Milan, Milan, Italy.; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Heckenbach+I%22">Heckenbach I</searchLink>; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Scheibye-Knudsen+M%22">Scheibye-Knudsen M</searchLink>; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Deleidi+M%22">Deleidi M</searchLink>; Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France. michela.deleidi@institutimagine.org.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. michela.deleidi@institutimagine.org.
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