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The association of frailty with age and lifespan in mice differs by strain and sex.

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Title: The association of frailty with age and lifespan in mice differs by strain and sex.
Authors: Zhu D; Institute for Systems Biology, Seattle, Washington, United States., Green CL; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.; Centre for Nutrition, Exercise and Metabolism, Department for Health, University of Bath, Bath, United Kingdom., Mitchell SJ; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, New Jersey, United States., MacArthur MR; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, New Jersey, United States.; Department of Chemistry, Princeton University, Princeton, New Jersey, United States.; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, New Jersey, United States., Bisset ES; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada., Mach J; Kolling Institute, Northern Sydney Local Health District and The University of Sydney, St Leonards, New South Wales, Australia., Wu JZ; Institute for Systems Biology, Seattle, Washington, United States., Samuelson BA; Institute for Systems Biology, Seattle, Washington, United States., Shindyapina A; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.; Retro Biosciences, San Francisco, California, United States., Moldakozhayev A; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.; Metabolic Disorders and Complications, and Brain Repair and Integrative Neuroscience Programs, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Tskhay A; Department of Family Medicine, McGill University, Montreal, Quebec, Canada.; CHU Sainte-Justine Research Centre, Montreal, Quebec, Canada., Tyshkovskiy A; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States., Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States., Sinclair DA; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, Massachusetts, United States., Howlett SE; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Medicine (Geriatric Medicine), Dalhousie University, Halifax, Nova Scotia, Canada., Hilmer SN; Kolling Institute, Northern Sydney Local Health District and The University of Sydney, St Leonards, New South Wales, Australia., Lamming DW; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.; Wisconsin Nathan Shock Center of Excellence in the Basic Biology of Aging, Madison, Wisconsin, United States., Kane AE; Institute for Systems Biology, Seattle, Washington, United States.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States.
Source: The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2026 Jul 01; Vol. 81 (8).
Publication Type: Journal Article
Journal Info: Publisher: published on behalf of the Gerontological Society of America by Oxford University Press Country of Publication: United States NLM ID: 9502837 Publication Model: Print Cited Medium: Internet ISSN: 1758-535X (Electronic) Linking ISSN: 10795006 NLM ISO Abbreviation: J Gerontol A Biol Sci Med Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhu+D%22">Zhu D</searchLink>; Institute for Systems Biology, Seattle, Washington, United States.<br /><searchLink fieldCode="AU" term="%22Green+CL%22">Green CL</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.; Centre for Nutrition, Exercise and Metabolism, Department for Health, University of Bath, Bath, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mitchell+SJ%22">Mitchell SJ</searchLink>; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22MacArthur+MR%22">MacArthur MR</searchLink>; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, New Jersey, United States.; Department of Chemistry, Princeton University, Princeton, New Jersey, United States.; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22Bisset+ES%22">Bisset ES</searchLink>; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Mach+J%22">Mach J</searchLink>; Kolling Institute, Northern Sydney Local Health District and The University of Sydney, St Leonards, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Wu+JZ%22">Wu JZ</searchLink>; Institute for Systems Biology, Seattle, Washington, United States.<br /><searchLink fieldCode="AU" term="%22Samuelson+BA%22">Samuelson BA</searchLink>; Institute for Systems Biology, Seattle, Washington, United States.<br /><searchLink fieldCode="AU" term="%22Shindyapina+A%22">Shindyapina A</searchLink>; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.; Retro Biosciences, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Moldakozhayev+A%22">Moldakozhayev A</searchLink>; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.; Metabolic Disorders and Complications, and Brain Repair and Integrative Neuroscience Programs, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Tskhay+A%22">Tskhay A</searchLink>; Department of Family Medicine, McGill University, Montreal, Quebec, Canada.; CHU Sainte-Justine Research Centre, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Tyshkovskiy+A%22">Tyshkovskiy A</searchLink>; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.<br /><searchLink fieldCode="AU" term="%22Gladyshev+VN%22">Gladyshev VN</searchLink>; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States.<br /><searchLink fieldCode="AU" term="%22Sinclair+DA%22">Sinclair DA</searchLink>; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, Massachusetts, United States.<br /><searchLink fieldCode="AU" term="%22Howlett+SE%22">Howlett SE</searchLink>; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Medicine (Geriatric Medicine), Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Hilmer+SN%22">Hilmer SN</searchLink>; Kolling Institute, Northern Sydney Local Health District and The University of Sydney, St Leonards, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Lamming+DW%22">Lamming DW</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.; Wisconsin Nathan Shock Center of Excellence in the Basic Biology of Aging, Madison, Wisconsin, United States.<br /><searchLink fieldCode="AU" term="%22Kane+AE%22">Kane AE</searchLink>; Institute for Systems Biology, Seattle, Washington, United States.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States.
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