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Persistence of large mtDNA rearrangements linked to premature aging in Pol γ exonuclease-deficient mice.

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Title: Persistence of large mtDNA rearrangements linked to premature aging in Pol γ exonuclease-deficient mice.
Authors: Wu S; Genome Integrity and Structural Biology Laboratory, Mitochondrial DNA Replication Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States., Lujan SA; Genome Integrity and Structural Biology Laboratory, DNA Replication Fidelity Group, National Institute of Environmental Health Sciences, National Institutes of Health,, Research Triangle Park, NC 27709,United States., Burkholder AB; Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States., Nissanka N; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136,United States., Longley MJ; Genome Integrity and Structural Biology Laboratory, Mitochondrial DNA Replication Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States., Mieczkowski P; Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, United States., Kunkel TA; Genome Integrity and Structural Biology Laboratory, DNA Replication Fidelity Group, National Institute of Environmental Health Sciences, National Institutes of Health,, Research Triangle Park, NC 27709,United States., Moraes CT; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136,United States., Copeland WC; Genome Integrity and Structural Biology Laboratory, Mitochondrial DNA Replication Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States.
Source: Nucleic acids research [Nucleic Acids Res] 2026 Jun 22; Vol. 54 (12).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: Persistence of large mtDNA rearrangements linked to premature aging in Pol γ exonuclease-deficient mice.
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  Data: <searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; Genome Integrity and Structural Biology Laboratory, Mitochondrial DNA Replication Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States.<br /><searchLink fieldCode="AU" term="%22Lujan+SA%22">Lujan SA</searchLink>; Genome Integrity and Structural Biology Laboratory, DNA Replication Fidelity Group, National Institute of Environmental Health Sciences, National Institutes of Health,, Research Triangle Park, NC 27709,United States.<br /><searchLink fieldCode="AU" term="%22Burkholder+AB%22">Burkholder AB</searchLink>; Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States.<br /><searchLink fieldCode="AU" term="%22Nissanka+N%22">Nissanka N</searchLink>; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136,United States.<br /><searchLink fieldCode="AU" term="%22Longley+MJ%22">Longley MJ</searchLink>; Genome Integrity and Structural Biology Laboratory, Mitochondrial DNA Replication Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States.<br /><searchLink fieldCode="AU" term="%22Mieczkowski+P%22">Mieczkowski P</searchLink>; Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, United States.<br /><searchLink fieldCode="AU" term="%22Kunkel+TA%22">Kunkel TA</searchLink>; Genome Integrity and Structural Biology Laboratory, DNA Replication Fidelity Group, National Institute of Environmental Health Sciences, National Institutes of Health,, Research Triangle Park, NC 27709,United States.<br /><searchLink fieldCode="AU" term="%22Moraes+CT%22">Moraes CT</searchLink>; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136,United States.<br /><searchLink fieldCode="AU" term="%22Copeland+WC%22">Copeland WC</searchLink>; Genome Integrity and Structural Biology Laboratory, Mitochondrial DNA Replication Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0411011 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1362-4962 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203051048%22">03051048 </searchLink><i>NLM ISO Abbreviation: </i>Nucleic Acids Res <i>Subsets: </i>MEDLINE; In Process
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        Value: 10.1093/nar/gkag648
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              Text: 2026 Jun 22
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