Inhibition of PfCLK3 interferes with malaria parasite RNA splicing and explains the mechanism of action of a new class of antimalarial candidates.
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| Title: | Inhibition of PfCLK3 interferes with malaria parasite RNA splicing and explains the mechanism of action of a new class of antimalarial candidates. |
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| Authors: | Janha O; Keltic Pharma Therapeutics Limited, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom., Olaniyan N; School of Molecular Biosciences, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom., Diam GK; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Sharma S; Keltic Pharma Therapeutics Limited, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom., Beraldi D; School of infection and Immunity, College of Medical, Veterinary and Life Science, University of Glasgow, Glasgow, United Kingdom., Jamieson AG; School of Chemistry Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom., Bozdech Z; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Tobin AB; School of Molecular Biosciences, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom., Modrzynska K; School of infection and Immunity, College of Medical, Veterinary and Life Science, University of Glasgow, Glasgow, United Kingdom. |
| Source: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2026 Jun 22, pp. e0156125. Date of Electronic Publication: 2026 Jun 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42363832 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Inhibition of PfCLK3 interferes with malaria parasite RNA splicing and explains the mechanism of action of a new class of antimalarial candidates. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Janha+O%22">Janha O</searchLink>; Keltic Pharma Therapeutics Limited, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Olaniyan+N%22">Olaniyan N</searchLink>; School of Molecular Biosciences, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Diam+GK%22">Diam GK</searchLink>; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Sharma+S%22">Sharma S</searchLink>; Keltic Pharma Therapeutics Limited, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Beraldi+D%22">Beraldi D</searchLink>; School of infection and Immunity, College of Medical, Veterinary and Life Science, University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Jamieson+AG%22">Jamieson AG</searchLink>; School of Chemistry Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bozdech+Z%22">Bozdech Z</searchLink>; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tobin+AB%22">Tobin AB</searchLink>; School of Molecular Biosciences, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Modrzynska+K%22">Modrzynska K</searchLink>; School of infection and Immunity, College of Medical, Veterinary and Life Science, University of Glasgow, Glasgow, United Kingdom. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220315061%22">Antimicrobial agents and chemotherapy</searchLink> [Antimicrob Agents Chemother] 2026 Jun 22, pp. e0156125. <i>Date of Electronic Publication: </i>2026 Jun 22. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Microbiology%22">American Society for Microbiology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0315061 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1098-6596 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200664804%22">00664804 </searchLink><i>NLM ISO Abbreviation: </i>Antimicrob Agents Chemother <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42363832 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1128/aac.01561-25 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e0156125 Titles: – TitleFull: Inhibition of PfCLK3 interferes with malaria parasite RNA splicing and explains the mechanism of action of a new class of antimalarial candidates. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Janha O – PersonEntity: Name: NameFull: Olaniyan N – PersonEntity: Name: NameFull: Diam GK – PersonEntity: Name: NameFull: Sharma S – PersonEntity: Name: NameFull: Beraldi D – PersonEntity: Name: NameFull: Jamieson AG – PersonEntity: Name: NameFull: Bozdech Z – PersonEntity: Name: NameFull: Tobin AB – PersonEntity: Name: NameFull: Modrzynska K IsPartOfRelationships: – BibEntity: Dates: – D: 22 M: 06 Text: 2026 Jun 22 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1098-6596 Titles: – TitleFull: Antimicrobial agents and chemotherapy Type: main |
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