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Identification of key metabolic enzymes involved in the activation of obeldesivir and remdesivir to the active triphosphate metabolite.

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Title: Identification of key metabolic enzymes involved in the activation of obeldesivir and remdesivir to the active triphosphate metabolite.
Authors: Xu Y; Gilead Sciences, Inc., Foster City, California, USA., Liclican A; Gilead Sciences, Inc., Foster City, California, USA., Zhao X; Gilead Sciences, Inc., Foster City, California, USA., Chen C; Gilead Sciences, Inc., Foster City, California, USA., Ortega JT; Gilead Sciences, Inc., Foster City, California, USA., Chuang H-C; Gilead Sciences, Inc., Foster City, California, USA., Soulette C; Gilead Sciences, Inc., Foster City, California, USA., Chaudhuri S; Gilead Sciences, Inc., Foster City, California, USA., Zhang J; Gilead Sciences, Inc., Foster City, California, USA., Wang T; Gilead Sciences, Inc., Foster City, California, USA., Babusis D; Gilead Sciences, Inc., Foster City, California, USA., Marchand B; Gilead Sciences, Inc., Foster City, California, USA., Sun K-h; Gilead Sciences, Inc., Foster City, California, USA., Ramirez R; Gilead Sciences, Inc., Foster City, California, USA., Ma B; Gilead Sciences, Inc., Foster City, California, USA., Nayak A; Gilead Sciences, Inc., Foster City, California, USA., Wang L; Department of Animal Biosciences, Swedish University of Agricultural Sciences, Uppsala, Sweden., Menon S; Gilead Sciences, Inc., Foster City, California, USA., Belzile J-P; Gilead Sciences, Inc., Foster City, California, USA., Lai Y; Gilead Sciences, Inc., Foster City, California, USA., Li L; Gilead Sciences, Inc., Foster City, California, USA., Mackman RL; Gilead Sciences, Inc., Foster City, California, USA., Bilello JP; Gilead Sciences, Inc., Foster City, California, USA., Cihlar T; Gilead Sciences, Inc., Foster City, California, USA., Feng JY; Gilead Sciences, Inc., Foster City, California, USA., Lad L; Gilead Sciences, Inc., Foster City, California, USA.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2026 Jun 22, pp. e0005526. Date of Electronic Publication: 2026 Jun 22.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification of key metabolic enzymes involved in the activation of obeldesivir and remdesivir to the active triphosphate metabolite.
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  Data: <searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Liclican+A%22">Liclican A</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Ortega+JT%22">Ortega JT</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Chuang+H-C%22">Chuang H-C</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Soulette+C%22">Soulette C</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Chaudhuri+S%22">Chaudhuri S</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Babusis+D%22">Babusis D</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Marchand+B%22">Marchand B</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Sun+K-h%22">Sun K-h</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Ramirez+R%22">Ramirez R</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Ma+B%22">Ma B</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Nayak+A%22">Nayak A</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Animal Biosciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Menon+S%22">Menon S</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Belzile+J-P%22">Belzile J-P</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Lai+Y%22">Lai Y</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Mackman+RL%22">Mackman RL</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Bilello+JP%22">Bilello JP</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Cihlar+T%22">Cihlar T</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Feng+JY%22">Feng JY</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Lad+L%22">Lad L</searchLink>; Gilead Sciences, Inc., Foster City, California, USA.
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  Data: <searchLink fieldCode="JN" term="%220315061%22">Antimicrobial agents and chemotherapy</searchLink> [Antimicrob Agents Chemother] 2026 Jun 22, pp. e0005526. <i>Date of Electronic Publication: </i>2026 Jun 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Microbiology%22">American Society for Microbiology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0315061 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1098-6596 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200664804%22">00664804 </searchLink><i>NLM ISO Abbreviation: </i>Antimicrob Agents Chemother <i>Subsets: </i>MEDLINE
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