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Limited predictive value of PD-L1 TPS for pathological response in NSCLC is not attributable to interobserver variability.

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Title: Limited predictive value of PD-L1 TPS for pathological response in NSCLC is not attributable to interobserver variability.
Authors: Steinestel K; Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, Ulm, Germany. Electronic address: konrad@steinestel.com., Löwer-Kiem LM; Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, Ulm, Germany., Ambrosi F; Maggiore Hospital, University of Bologna, Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Becker AS; Institute of Pathology, University Medical Center, Rostock, Germany., Bohnenberger H; Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany., Bräutigam K; Centre for Evolution and Cancer, Institute of Cancer Research, London, UK; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Cazzato G; Section of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari 'Aldo Moro', Bari, Italy., Conde E; Department of Pathology, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Molecular and Computational Pathology Group, Research Institute Hospital 12 de Octubre (imas12), CIBERONC, Madrid, Spain., Cozac-Szőke AR; Pathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures 540142 Targu Mures, Romania., Curto D; Department of Pathology, Hospital Universitario 12 de Octubre, Molecular and Computational Pathology Group, Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain., Dahlberg JO; Växjö Hospital, Pathology and Cytology, Växjö, Sweden., Gama JM; Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP) / CI-IPOP@RISE Health Research Network - Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal., Gambella A; Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy; IRCCS Azienda Ospedaliera Metropolitana (IRCCS AOM), Genoa, Italy., Hutarew G; Institute of Pathology, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria., Lopez-Rios F; Department of Pathology, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Molecular and Computational Pathology Group, Research Institute Hospital 12 de Octubre (imas12), CIBERONC, Madrid, Spain., Lucà S; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine University of Campania Luigi Vanvitelli Naples, Italy., Lunardi F; Department of Molecular Medicine Unit of Anatomic Pathology, University of Pavia, Pavia, Italy; Unit of Pathological Anatomy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Matek C; Institute of Pathology, University Hospital Erlangen, Erlangen, Germany; Comprehensive Cancer Center EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen Nürnberg, Erlangen, Germany; Bavarian Cancer Research Center (BZKF), Erlangen, Germany., Meyer C; Department of Pathology, Klinikum Nuremberg, Paracelsus Medical University, Nuremberg, Germany., Olteanu GE; The University of Pharmacy and Medicine ''Victor Babes'', Timisoara, Romania; The Royal Brompton, Cellular Pathology Department, London, UK., Popper H; Diagnostic and Research Institute of Pathology Medical University of Graz, Graz, Austria., Roden AC; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Samaras MG; Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece., Skok K; Diagnostic and Research Institute of Pathology Medical University of Graz, Graz, Austria; Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia., Suster D; Department of Pathology, Rutgers University, New Jersey Medical School, Newark, NJ, USA., Weissferdt A; Section of Thoracic Pathology, Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA., Zustin J; Gemeinschaftspraxis Für Pathologie Regensburg, Regensburg Germany., Kümpers C; Institute of Pathology, University Hospital Schleswig-Holstein, Lübeck, Germany., Elsner F; Institute of Pathology, University Hospital Erlangen, Erlangen, Germany; Comprehensive Cancer Center EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen Nürnberg, Erlangen, Germany; Bavarian Cancer Research Center (BZKF), Erlangen, Germany.
Source: Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2026 Aug; Vol. 218, pp. 109510. Date of Electronic Publication: 2026 Jun 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8800805 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8332 (Electronic) Linking ISSN: 01695002 NLM ISO Abbreviation: Lung Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Limited predictive value of PD-L1 TPS for pathological response in NSCLC is not attributable to interobserver variability.
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  Data: <searchLink fieldCode="AU" term="%22Steinestel+K%22">Steinestel K</searchLink>; Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, Ulm, Germany. Electronic address: konrad@steinestel.com.<br /><searchLink fieldCode="AU" term="%22Löwer-Kiem+LM%22">Löwer-Kiem LM</searchLink>; Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Ambrosi+F%22">Ambrosi F</searchLink>; Maggiore Hospital, University of Bologna, Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Becker+AS%22">Becker AS</searchLink>; Institute of Pathology, University Medical Center, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Bohnenberger+H%22">Bohnenberger H</searchLink>; Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Bräutigam+K%22">Bräutigam K</searchLink>; Centre for Evolution and Cancer, Institute of Cancer Research, London, UK; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cazzato+G%22">Cazzato G</searchLink>; Section of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Conde+E%22">Conde E</searchLink>; Department of Pathology, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Molecular and Computational Pathology Group, Research Institute Hospital 12 de Octubre (imas12), CIBERONC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cozac-Szőke+AR%22">Cozac-Szőke AR</searchLink>; Pathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures 540142 Targu Mures, Romania.<br /><searchLink fieldCode="AU" term="%22Curto+D%22">Curto D</searchLink>; Department of Pathology, Hospital Universitario 12 de Octubre, Molecular and Computational Pathology Group, Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Dahlberg+JO%22">Dahlberg JO</searchLink>; Växjö Hospital, Pathology and Cytology, Växjö, Sweden.<br /><searchLink fieldCode="AU" term="%22Gama+JM%22">Gama JM</searchLink>; Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP) / CI-IPOP@RISE Health Research Network - Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Gambella+A%22">Gambella A</searchLink>; Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy; IRCCS Azienda Ospedaliera Metropolitana (IRCCS AOM), Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Hutarew+G%22">Hutarew G</searchLink>; Institute of Pathology, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.<br /><searchLink fieldCode="AU" term="%22Lopez-Rios+F%22">Lopez-Rios F</searchLink>; Department of Pathology, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Molecular and Computational Pathology Group, Research Institute Hospital 12 de Octubre (imas12), CIBERONC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lucà+S%22">Lucà S</searchLink>; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine University of Campania Luigi Vanvitelli Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Lunardi+F%22">Lunardi F</searchLink>; Department of Molecular Medicine Unit of Anatomic Pathology, University of Pavia, Pavia, Italy; Unit of Pathological Anatomy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Matek+C%22">Matek C</searchLink>; Institute of Pathology, University Hospital Erlangen, Erlangen, Germany; Comprehensive Cancer Center EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen Nürnberg, Erlangen, Germany; Bavarian Cancer Research Center (BZKF), Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Meyer+C%22">Meyer C</searchLink>; Department of Pathology, Klinikum Nuremberg, Paracelsus Medical University, Nuremberg, Germany.<br /><searchLink fieldCode="AU" term="%22Olteanu+GE%22">Olteanu GE</searchLink>; The University of Pharmacy and Medicine ''Victor Babes'', Timisoara, Romania; The Royal Brompton, Cellular Pathology Department, London, UK.<br /><searchLink fieldCode="AU" term="%22Popper+H%22">Popper H</searchLink>; Diagnostic and Research Institute of Pathology Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Roden+AC%22">Roden AC</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Samaras+MG%22">Samaras MG</searchLink>; Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Skok+K%22">Skok K</searchLink>; Diagnostic and Research Institute of Pathology Medical University of Graz, Graz, Austria; Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia.<br /><searchLink fieldCode="AU" term="%22Suster+D%22">Suster D</searchLink>; Department of Pathology, Rutgers University, New Jersey Medical School, Newark, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Weissferdt+A%22">Weissferdt A</searchLink>; Section of Thoracic Pathology, Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zustin+J%22">Zustin J</searchLink>; Gemeinschaftspraxis Für Pathologie Regensburg, Regensburg Germany.<br /><searchLink fieldCode="AU" term="%22Kümpers+C%22">Kümpers C</searchLink>; Institute of Pathology, University Hospital Schleswig-Holstein, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Elsner+F%22">Elsner F</searchLink>; Institute of Pathology, University Hospital Erlangen, Erlangen, Germany; Comprehensive Cancer Center EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen Nürnberg, Erlangen, Germany; Bavarian Cancer Research Center (BZKF), Erlangen, Germany.
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  Data: <searchLink fieldCode="JN" term="%228800805%22">Lung cancer (Amsterdam, Netherlands)</searchLink> [Lung Cancer] 2026 Aug; Vol. 218, pp. 109510. <i>Date of Electronic Publication: </i>2026 Jun 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Scientific+Publishers%22">Elsevier Scientific Publishers </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>8800805 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-8332 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201695002%22">01695002 </searchLink><i>NLM ISO Abbreviation: </i>Lung Cancer <i>Subsets: </i>MEDLINE
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