PRO-PLATINUM: A randomized, double-blind, placebo controlled study to investigate the efficacy of a probiotic intervention on the gut and vaginal microbiome of ovarian cancer patients undergoing treatment with platinum chemotherapy.

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Title: PRO-PLATINUM: A randomized, double-blind, placebo controlled study to investigate the efficacy of a probiotic intervention on the gut and vaginal microbiome of ovarian cancer patients undergoing treatment with platinum chemotherapy.
Authors: Chambers LM; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. Electronic address: laura.chambers@osumc.edu., Spakowicz D; Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Chalif J; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., O'Connor R; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Kistenfeger Q; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Mehra Y; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA; Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Mohssen M; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA; Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Abdeen C; The Ohio State University School of Medicine, USA., Haight P; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Nagel C; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Neff R; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Cohn D; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Copeland LJ; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Backes F; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Cosgrove C; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Hays J; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Dravillas C; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., McLaughlin E; The Ohio State University School of Medicine, Department of Biostatistics, USA., O'Malley D; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.
Source: Gynecologic oncology [Gynecol Oncol] 2026 Jun 27; Vol. 211, pp. 74-78. Date of Electronic Publication: 2026 Jun 27.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0365304 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6859 (Electronic) Linking ISSN: 00908258 NLM ISO Abbreviation: Gynecol Oncol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Chambers+LM%22">Chambers LM</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. Electronic address: laura.chambers@osumc.edu.<br /><searchLink fieldCode="AU" term="%22Spakowicz+D%22">Spakowicz D</searchLink>; Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Chalif+J%22">Chalif J</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22O'Connor+R%22">O'Connor R</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Kistenfeger+Q%22">Kistenfeger Q</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Mehra+Y%22">Mehra Y</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA; Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Mohssen+M%22">Mohssen M</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA; Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Abdeen+C%22">Abdeen C</searchLink>; The Ohio State University School of Medicine, USA.<br /><searchLink fieldCode="AU" term="%22Haight+P%22">Haight P</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Nagel+C%22">Nagel C</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Neff+R%22">Neff R</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Cohn+D%22">Cohn D</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Copeland+LJ%22">Copeland LJ</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Backes+F%22">Backes F</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Cosgrove+C%22">Cosgrove C</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hays+J%22">Hays J</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Dravillas+C%22">Dravillas C</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22McLaughlin+E%22">McLaughlin E</searchLink>; The Ohio State University School of Medicine, Department of Biostatistics, USA.<br /><searchLink fieldCode="AU" term="%22O'Malley+D%22">O'Malley D</searchLink>; Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.
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  Data: <searchLink fieldCode="JN" term="%220365304%22">Gynecologic oncology</searchLink> [Gynecol Oncol] 2026 Jun 27; Vol. 211, pp. 74-78. <i>Date of Electronic Publication: </i>2026 Jun 27.
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        Value: 10.1016/j.ygyno.2026.06.016
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