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PBPK Modeling and Clinical Data Reveal Reduced Impact of CYP3A4 and CYP2C9 Inhibitors on Elimination of Siponimod.

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Title: PBPK Modeling and Clinical Data Reveal Reduced Impact of CYP3A4 and CYP2C9 Inhibitors on Elimination of Siponimod.
Authors: Huth F; Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland., Shakeri-Nejad K; Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland., Gardin A; Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland., Shah B; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA., Pohl O; Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland., Pezous N; Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland., Faller T; Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland.
Source: Clinical and translational science [Clin Transl Sci] 2026 Jul; Vol. 19 (7), pp. e70657.
Publication Type: Journal Article
Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PBPK Modeling and Clinical Data Reveal Reduced Impact of CYP3A4 and CYP2C9 Inhibitors on Elimination of Siponimod.
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  Data: <searchLink fieldCode="AU" term="%22Huth+F%22">Huth F</searchLink>; Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Shakeri-Nejad+K%22">Shakeri-Nejad K</searchLink>; Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gardin+A%22">Gardin A</searchLink>; Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Shah+B%22">Shah B</searchLink>; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Pohl+O%22">Pohl O</searchLink>; Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pezous+N%22">Pezous N</searchLink>; Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Faller+T%22">Faller T</searchLink>; Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland.
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        Value: 10.1111/cts.70657
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              Text: 2026 Jul
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              Y: 2026
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