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Decoding candidemia in critically ill patients: unsupervised clustering identifies three unique phenotypes.

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Title: Decoding candidemia in critically ill patients: unsupervised clustering identifies three unique phenotypes.
Authors: Reizine F; Service de Réanimation Polyvalente, Vannes Hospital Center, 56000, Vannes, France. florian.reizine@gmail.com., Henry J; Service de Médecine Intensive-Réanimation, Bordeaux University Hospital, 33000, Bordeaux, France., Desmedt L; Service de Médecine Intensive-Réanimation, Nantes University Hospital, 44000, Nantes, France., Camus C; Service de Réanimation Médicale, Rennes University Hospital, 35000, Rennes, France., Coirier V; Service de Réanimation Médicale, Rennes University Hospital, 35000, Rennes, France., Arrive F; Service de Médecine Intensive-Réanimation, Poitiers University Hospital, 86000, Poitiers, France., Burban E; Service de Médecine Intensive-Réanimation, Brest University Hospital, 29200, Brest, France., Eustache G; Service de Réanimation Chirurgicale, Rennes University Hospital, 35000, Rennes, France., Belleville T; Service de Réanimation Chirurgicale, Brest University Hospital, 29200, Rennes, France., Marc A; Service de Réanimation Polyvalente, La Roche-Sur-Yon Hospital Center, 85000, La Roche-Sur-Yon, France., Malherbe J; Service de Médecine Intensive-Réanimation, Caen University Hospital, 14000, Caen, France., Bouju P; Service de Réanimation Polyvalente, Lorient Hospital Center, 56322, Lorient, France., Jaubert P; Service de Médecine Intensive-Réanimation, Angers University Hospital, 49100, Angers, France., Lesieur O; Service de Réanimation Polyvalente, La Rochelle Hospital Center, 17019, La Rochelle, France., Leclerc M; Service de Réanimation Polyvalente, Saint-Lô Hospital Center, 50000, Saint-Lô, France., Fillâtre P; Service de Réanimation Polyvalente, Saint-Brieuc Hospital Center, 22000, Saint-Brieuc, France., Frérou A; Service de Réanimation Polyvalente, Saint-Malo Hospital Center, 35400, Saint-Malo, France., Prével R; Service de Médecine Intensive-Réanimation, Bordeaux University Hospital, 33000, Bordeaux, France., Mainguy N; Service de Réanimation Polyvalente, Vannes Hospital Center, 56000, Vannes, France., Cady A; Laboratoire de Microbiologie, Vannes Hospital Center, 56000, Vannes, France., Morio F; Laboratoire de Parasitologie-Mycologie, Nantes University Hospital, 44000, Nantes, France., Le Gal S; Laboratoire de Parasitologie-Mycologie, Brest University Hospital, 29200, Brest, France., Perraud E; Laboratoire de Parasitologie-Mycologie, Poitiers University Hospital, 86000, Poitiers, France., Delhaes L; Laboratoire de Parasitologie-Mycologie, Bordeaux University Hospital, 33000, Bordeaux, France., Imbert S; Laboratoire de Parasitologie-Mycologie, Bordeaux University Hospital, 33000, Bordeaux, France., Guegan H; Laboratoire de Parasitologie-Mycologie, European ECMM Excellence Center in Medical Mycology, CHU Rennes, Centre National de Référence Pour Les Mycoses Et Antifongiques-Laboratoire Associé Aspergilloses Chroniques, Rennes, France.; Inserm, EHESP, IRSET (Institut de Recherche en, Univ Rennes, Santé Environnement Et Travail) - UMR_S 1085, Rennes, France., Bonhomme J; Laboratoire de Parasitologie-Mycologie, Caen University Hospital, ToxEMAC-ABTE, Université de Normandie Unicaen 14000, Caen, France., Pihet M; Laboratoire de Parasitologie-Mycologie, Angers University Hospital, 49100, Angers, France., Dupin C; Laboratoire de Parasitologie-Mycologie, Saint-Brieuc Hospital, 22000, Saint Brieuc, France., Delbove A; Service de Réanimation Polyvalente, Vannes Hospital Center, 56000, Vannes, France., Du Cheyron D; Service de Médecine Intensive-Réanimation, Caen University Hospital, 14000, Caen, France., Launey Y; Service de Réanimation Chirurgicale, Rennes University Hospital, 35000, Rennes, France., Aubron C; Service de Médecine Intensive-Réanimation, Brest University Hospital, 29200, Brest, France., Gangneux JP; Laboratoire de Parasitologie-Mycologie, European ECMM Excellence Center in Medical Mycology, CHU Rennes, Centre National de Référence Pour Les Mycoses Et Antifongiques-Laboratoire Associé Aspergilloses Chroniques, Rennes, France. jean-pierre.gangneux@chu-rennes.fr.; Inserm, EHESP, IRSET (Institut de Recherche en, Univ Rennes, Santé Environnement Et Travail) - UMR_S 1085, Rennes, France. jean-pierre.gangneux@chu-rennes.fr.
Source: Critical care (London, England) [Crit Care] 2026 Jun 28. Date of Electronic Publication: 2026 Jun 28.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Decoding candidemia in critically ill patients: unsupervised clustering identifies three unique phenotypes.
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  Data: <searchLink fieldCode="AU" term="%22Reizine+F%22">Reizine F</searchLink>; Service de Réanimation Polyvalente, Vannes Hospital Center, 56000, Vannes, France. florian.reizine@gmail.com.<br /><searchLink fieldCode="AU" term="%22Henry+J%22">Henry J</searchLink>; Service de Médecine Intensive-Réanimation, Bordeaux University Hospital, 33000, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Desmedt+L%22">Desmedt L</searchLink>; Service de Médecine Intensive-Réanimation, Nantes University Hospital, 44000, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Camus+C%22">Camus C</searchLink>; Service de Réanimation Médicale, Rennes University Hospital, 35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Coirier+V%22">Coirier V</searchLink>; Service de Réanimation Médicale, Rennes University Hospital, 35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Arrive+F%22">Arrive F</searchLink>; Service de Médecine Intensive-Réanimation, Poitiers University Hospital, 86000, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Burban+E%22">Burban E</searchLink>; Service de Médecine Intensive-Réanimation, Brest University Hospital, 29200, Brest, France.<br /><searchLink fieldCode="AU" term="%22Eustache+G%22">Eustache G</searchLink>; Service de Réanimation Chirurgicale, Rennes University Hospital, 35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Belleville+T%22">Belleville T</searchLink>; Service de Réanimation Chirurgicale, Brest University Hospital, 29200, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Marc+A%22">Marc A</searchLink>; Service de Réanimation Polyvalente, La Roche-Sur-Yon Hospital Center, 85000, La Roche-Sur-Yon, France.<br /><searchLink fieldCode="AU" term="%22Malherbe+J%22">Malherbe J</searchLink>; Service de Médecine Intensive-Réanimation, Caen University Hospital, 14000, Caen, France.<br /><searchLink fieldCode="AU" term="%22Bouju+P%22">Bouju P</searchLink>; Service de Réanimation Polyvalente, Lorient Hospital Center, 56322, Lorient, France.<br /><searchLink fieldCode="AU" term="%22Jaubert+P%22">Jaubert P</searchLink>; Service de Médecine Intensive-Réanimation, Angers University Hospital, 49100, Angers, France.<br /><searchLink fieldCode="AU" term="%22Lesieur+O%22">Lesieur O</searchLink>; Service de Réanimation Polyvalente, La Rochelle Hospital Center, 17019, La Rochelle, France.<br /><searchLink fieldCode="AU" term="%22Leclerc+M%22">Leclerc M</searchLink>; Service de Réanimation Polyvalente, Saint-Lô Hospital Center, 50000, Saint-Lô, France.<br /><searchLink fieldCode="AU" term="%22Fillâtre+P%22">Fillâtre P</searchLink>; Service de Réanimation Polyvalente, Saint-Brieuc Hospital Center, 22000, Saint-Brieuc, France.<br /><searchLink fieldCode="AU" term="%22Frérou+A%22">Frérou A</searchLink>; Service de Réanimation Polyvalente, Saint-Malo Hospital Center, 35400, Saint-Malo, France.<br /><searchLink fieldCode="AU" term="%22Prével+R%22">Prével R</searchLink>; Service de Médecine Intensive-Réanimation, Bordeaux University Hospital, 33000, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Mainguy+N%22">Mainguy N</searchLink>; Service de Réanimation Polyvalente, Vannes Hospital Center, 56000, Vannes, France.<br /><searchLink fieldCode="AU" term="%22Cady+A%22">Cady A</searchLink>; Laboratoire de Microbiologie, Vannes Hospital Center, 56000, Vannes, France.<br /><searchLink fieldCode="AU" term="%22Morio+F%22">Morio F</searchLink>; Laboratoire de Parasitologie-Mycologie, Nantes University Hospital, 44000, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Le+Gal+S%22">Le Gal S</searchLink>; Laboratoire de Parasitologie-Mycologie, Brest University Hospital, 29200, Brest, France.<br /><searchLink fieldCode="AU" term="%22Perraud+E%22">Perraud E</searchLink>; Laboratoire de Parasitologie-Mycologie, Poitiers University Hospital, 86000, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Delhaes+L%22">Delhaes L</searchLink>; Laboratoire de Parasitologie-Mycologie, Bordeaux University Hospital, 33000, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Imbert+S%22">Imbert S</searchLink>; Laboratoire de Parasitologie-Mycologie, Bordeaux University Hospital, 33000, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Guegan+H%22">Guegan H</searchLink>; Laboratoire de Parasitologie-Mycologie, European ECMM Excellence Center in Medical Mycology, CHU Rennes, Centre National de Référence Pour Les Mycoses Et Antifongiques-Laboratoire Associé Aspergilloses Chroniques, Rennes, France.; Inserm, EHESP, IRSET (Institut de Recherche en, Univ Rennes, Santé Environnement Et Travail) - UMR_S 1085, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Bonhomme+J%22">Bonhomme J</searchLink>; Laboratoire de Parasitologie-Mycologie, Caen University Hospital, ToxEMAC-ABTE, Université de Normandie Unicaen 14000, Caen, France.<br /><searchLink fieldCode="AU" term="%22Pihet+M%22">Pihet M</searchLink>; Laboratoire de Parasitologie-Mycologie, Angers University Hospital, 49100, Angers, France.<br /><searchLink fieldCode="AU" term="%22Dupin+C%22">Dupin C</searchLink>; Laboratoire de Parasitologie-Mycologie, Saint-Brieuc Hospital, 22000, Saint Brieuc, France.<br /><searchLink fieldCode="AU" term="%22Delbove+A%22">Delbove A</searchLink>; Service de Réanimation Polyvalente, Vannes Hospital Center, 56000, Vannes, France.<br /><searchLink fieldCode="AU" term="%22Du+Cheyron+D%22">Du Cheyron D</searchLink>; Service de Médecine Intensive-Réanimation, Caen University Hospital, 14000, Caen, France.<br /><searchLink fieldCode="AU" term="%22Launey+Y%22">Launey Y</searchLink>; Service de Réanimation Chirurgicale, Rennes University Hospital, 35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Aubron+C%22">Aubron C</searchLink>; Service de Médecine Intensive-Réanimation, Brest University Hospital, 29200, Brest, France.<br /><searchLink fieldCode="AU" term="%22Gangneux+JP%22">Gangneux JP</searchLink>; Laboratoire de Parasitologie-Mycologie, European ECMM Excellence Center in Medical Mycology, CHU Rennes, Centre National de Référence Pour Les Mycoses Et Antifongiques-Laboratoire Associé Aspergilloses Chroniques, Rennes, France. jean-pierre.gangneux@chu-rennes.fr.; Inserm, EHESP, IRSET (Institut de Recherche en, Univ Rennes, Santé Environnement Et Travail) - UMR_S 1085, Rennes, France. jean-pierre.gangneux@chu-rennes.fr.
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