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Inhibition of tRNA fragments dysregulated in human mTLE exacerbates pathology and seizure activity.

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Title: Inhibition of tRNA fragments dysregulated in human mTLE exacerbates pathology and seizure activity.
Authors: Puhakka N; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Vangoor VR; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands., Gomes-Duarte A; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands.; VectorY Therapeutics, Matrix Innovation Center VI, Science Park 408, 1098 XH, Amsterdam, The Netherlands., de Wit M; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands., Broekhoven M; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands., Wieg L; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands., van Kronenburg NCH; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands., Mossink B; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands., Magielse N; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands., Pasterkamp RJ; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands. r.j.pasterkamp@umcutrecht.nl.
Source: Acta neuropathologica [Acta Neuropathol] 2026 Jun 28; Vol. 151 (1). Date of Electronic Publication: 2026 Jun 28.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
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  Data: Inhibition of tRNA fragments dysregulated in human mTLE exacerbates pathology and seizure activity.
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  Data: <searchLink fieldCode="AU" term="%22Puhakka+N%22">Puhakka N</searchLink>; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Vangoor+VR%22">Vangoor VR</searchLink>; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gomes-Duarte+A%22">Gomes-Duarte A</searchLink>; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands.; VectorY Therapeutics, Matrix Innovation Center VI, Science Park 408, 1098 XH, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Wit+M%22">de Wit M</searchLink>; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Broekhoven+M%22">Broekhoven M</searchLink>; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wieg+L%22">Wieg L</searchLink>; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Kronenburg+NCH%22">van Kronenburg NCH</searchLink>; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mossink+B%22">Mossink B</searchLink>; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Magielse+N%22">Magielse N</searchLink>; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pasterkamp+RJ%22">Pasterkamp RJ</searchLink>; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands. r.j.pasterkamp@umcutrecht.nl.
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  Data: <searchLink fieldCode="JN" term="%220412041%22">Acta neuropathologica</searchLink> [Acta Neuropathol] 2026 Jun 28; Vol. 151 (1). <i>Date of Electronic Publication: </i>2026 Jun 28.
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              Text: 2026 Jun 28
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