Inhibition of tRNA fragments dysregulated in human mTLE exacerbates pathology and seizure activity.
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| Title: | Inhibition of tRNA fragments dysregulated in human mTLE exacerbates pathology and seizure activity. |
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| Authors: | Puhakka N; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Vangoor VR; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands., Gomes-Duarte A; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands.; VectorY Therapeutics, Matrix Innovation Center VI, Science Park 408, 1098 XH, Amsterdam, The Netherlands., de Wit M; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands., Broekhoven M; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands., Wieg L; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands., van Kronenburg NCH; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands., Mossink B; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands., Magielse N; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands., Pasterkamp RJ; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG, Utrecht, The Netherlands. r.j.pasterkamp@umcutrecht.nl. |
| Source: | Acta neuropathologica [Acta Neuropathol] 2026 Jun 28; Vol. 151 (1). Date of Electronic Publication: 2026 Jun 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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