Hexokinase 2 upregulation is associated with glycolytic reprogramming and neuroinflammation in hypoxic-ischemic brain damage: a therapeutic target for early intervention.

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Title: Hexokinase 2 upregulation is associated with glycolytic reprogramming and neuroinflammation in hypoxic-ischemic brain damage: a therapeutic target for early intervention.
Authors: Li Y; Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Department of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Qin C; Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Department of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Miao C; Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Department of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Mu R; Department of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Department of Child Developmental Behavior, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Zhang P; Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Department of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Zhang B; Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Department of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Zhao X; Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Department of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Zhang X; Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Department of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Source: Frontiers in immunology [Front Immunol] 2026 Jun 12; Vol. 17, pp. 1837728. Date of Electronic Publication: 2026 Jun 12 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-3224
DOI:10.3389/fimmu.2026.1837728