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A controlled human infection model for symptomatic pertussis in North America using the pertactin-producing clinical isolate D420.

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Title: A controlled human infection model for symptomatic pertussis in North America using the pertactin-producing clinical isolate D420.
Authors: ElSherif MS; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Redden KL; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada., Langley JM; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Community Health and Epidemiology, Dalhousie University, Nova Scotia, Canada., Ye L; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada., Blanchard W; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada., Smith B; Department of Mathematics and Statistics, Dalhousie University, Halifax, Nova Scotia, Canada., Wang J; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada., Abu-Raya B; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada., Filliter JH; Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada., Edwards KM; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Creech CB; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., McNeil S; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Hatchette TF; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.; Division of Microbiology, Department of Pathology and Laboratory Medicine, Nova Scotia Health, Halifax, Nova Scotia, Canada., LeBlanc JJ; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.; Division of Microbiology, Department of Pathology and Laboratory Medicine, Nova Scotia Health, Halifax, Nova Scotia, Canada., Hariri S; Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Pawloski L; Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Maniatis P; Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Fox LM; Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Whittle CA; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada., Halperin SA; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Jun 15. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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DbLabel: MEDLINE Ultimate
An: 42369467
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: A controlled human infection model for symptomatic pertussis in North America using the pertactin-producing clinical isolate D420.
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  Data: <searchLink fieldCode="AU" term="%22ElSherif+MS%22">ElSherif MS</searchLink>; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.<br /><searchLink fieldCode="AU" term="%22Redden+KL%22">Redden KL</searchLink>; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.<br /><searchLink fieldCode="AU" term="%22Langley+JM%22">Langley JM</searchLink>; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Community Health and Epidemiology, Dalhousie University, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Ye+L%22">Ye L</searchLink>; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.<br /><searchLink fieldCode="AU" term="%22Blanchard+W%22">Blanchard W</searchLink>; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.<br /><searchLink fieldCode="AU" term="%22Smith+B%22">Smith B</searchLink>; Department of Mathematics and Statistics, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Abu-Raya+B%22">Abu-Raya B</searchLink>; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Filliter+JH%22">Filliter JH</searchLink>; Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Edwards+KM%22">Edwards KM</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Creech+CB%22">Creech CB</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22McNeil+S%22">McNeil S</searchLink>; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Hatchette+TF%22">Hatchette TF</searchLink>; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.; Division of Microbiology, Department of Pathology and Laboratory Medicine, Nova Scotia Health, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22LeBlanc+JJ%22">LeBlanc JJ</searchLink>; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.; Division of Microbiology, Department of Pathology and Laboratory Medicine, Nova Scotia Health, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Hariri+S%22">Hariri S</searchLink>; Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Pawloski+L%22">Pawloski L</searchLink>; Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Maniatis+P%22">Maniatis P</searchLink>; Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Fox+LM%22">Fox LM</searchLink>; Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Whittle+CA%22">Whittle CA</searchLink>; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.<br /><searchLink fieldCode="AU" term="%22Halperin+SA%22">Halperin SA</searchLink>; Canadian Center for Vaccinology (Dalhousie University, IWK Health, Nova Scotia Health), Halifax, NS, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2026 Jun 15. <i>Date of Electronic Publication: </i>2026 Jun 15.
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        Text: English
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