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CDK9 degrader induces BRCAness and sensitizes castration-resistant prostate cancer to PARP inhibitor.

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Title: CDK9 degrader induces BRCAness and sensitizes castration-resistant prostate cancer to PARP inhibitor.
Authors: Li J; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; Laboratory Animal Center, Fudan University, Shanghai 200032, China.; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai 200032, China., Sun J; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Tan W; Laboratory Animal Center, Fudan University, Shanghai 200032, China., Li G; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China., Xiao W; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Wu J; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China., Yang W; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China., Chen C; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; Laboratory Animal Center, Fudan University, Shanghai 200032, China., Li Y; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; Laboratory Animal Center, Fudan University, Shanghai 200032, China., Liu J; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; Laboratory Animal Center, Fudan University, Shanghai 200032, China., Liu Y; Laboratory Animal Center, Fudan University, Shanghai 200032, China., Liu D; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; Laboratory Animal Center, Fudan University, Shanghai 200032, China., Chen XH; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China., Zhu R; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; Laboratory Animal Center, Fudan University, Shanghai 200032, China., Huang R; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Yan J; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; Laboratory Animal Center, Fudan University, Shanghai 200032, China.
Source: Theranostics [Theranostics] 2026 Jun 17; Vol. 16 (13), pp. 7495-7513. Date of Electronic Publication: 2026 Jun 17 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CDK9 degrader induces BRCAness and sensitizes castration-resistant prostate cancer to PARP inhibitor.
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  Data: <searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; Laboratory Animal Center, Fudan University, Shanghai 200032, China.; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Tan+W%22">Tan W</searchLink>; Laboratory Animal Center, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.<br /><searchLink fieldCode="AU" term="%22Xiao+W%22">Xiao W</searchLink>; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China.<br /><searchLink fieldCode="AU" term="%22Yang+W%22">Yang W</searchLink>; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; Laboratory Animal Center, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; Laboratory Animal Center, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; Laboratory Animal Center, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Laboratory Animal Center, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Liu+D%22">Liu D</searchLink>; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; Laboratory Animal Center, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Chen+XH%22">Chen XH</searchLink>; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.<br /><searchLink fieldCode="AU" term="%22Zhu+R%22">Zhu R</searchLink>; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; Laboratory Animal Center, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Huang+R%22">Huang R</searchLink>; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Yan+J%22">Yan J</searchLink>; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; Laboratory Animal Center, Fudan University, Shanghai 200032, China.
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  Data: <searchLink fieldCode="JN" term="%22101552395%22">Theranostics</searchLink> [Theranostics] 2026 Jun 17; Vol. 16 (13), pp. 7495-7513. <i>Date of Electronic Publication: </i>2026 Jun 17 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ivyspring+International+Publisher%22">Ivyspring International Publisher </searchLink><i>Country of Publication: </i>Australia <i>NLM ID: </i>101552395 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1838-7640 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218387640%22">18387640 </searchLink><i>NLM ISO Abbreviation: </i>Theranostics <i>Subsets: </i>MEDLINE
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        Value: 10.7150/thno.131907
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      – TitleFull: CDK9 degrader induces BRCAness and sensitizes castration-resistant prostate cancer to PARP inhibitor.
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              Text: 2026 Jun 17
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