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FOXO1 Is Required for Growth and Viability of Cancer-Associated Fibroblasts in Human Breast Carcinomas.

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Title: FOXO1 Is Required for Growth and Viability of Cancer-Associated Fibroblasts in Human Breast Carcinomas.
Authors: Koyama T; Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Tokyo, Japan.; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan., Kobayashi T; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, Tokyo, Japan., Mezawa Y; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, Tokyo, Japan., Gao W; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, Tokyo, Japan., Yamada K; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan., Yamashita K; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, Tokyo, Japan., Wang Z; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, Tokyo, Japan., Koyama Y; Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Tokyo, Japan.; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan., Abe M; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan., Maruyama R; Division of Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan., Yang L; Division of Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan., Daitoku H; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan., Fukamizu A; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan., Takano A; Research Platform Office, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Medical Oncology and Cancer Center, and Center for Advanced Medicine Against Cancer, Shiga University of Medical Science, Otsu, Japan., Miyagi Y; Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan., Yokose T; Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan., Yamashita T; Department of Breast Surgery and Oncology, Kanagawa Cancer Center, Yokohama, Japan., Sugahara K; Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Tokyo, Japan., Seimiya H; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan., Daigo Y; Research Platform Office, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Medical Oncology and Cancer Center, and Center for Advanced Medicine Against Cancer, Shiga University of Medical Science, Otsu, Japan., Katakura A; Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Tokyo, Japan., Orimo A; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Faculty of Health Sciences, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Source: Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2026 Jul; Vol. 31 (4), pp. e70133.
Publication Type: Journal Article
Journal Info: Publisher: Blackwell Science Ltd Country of Publication: England NLM ID: 9607379 Publication Model: Print Cited Medium: Internet ISSN: 1365-2443 (Electronic) Linking ISSN: 13569597 NLM ISO Abbreviation: Genes Cells Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Koyama+T%22">Koyama T</searchLink>; Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Tokyo, Japan.; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+T%22">Kobayashi T</searchLink>; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Mezawa+Y%22">Mezawa Y</searchLink>; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Gao+W%22">Gao W</searchLink>; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamada+K%22">Yamada K</searchLink>; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamashita+K%22">Yamashita K</searchLink>; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Koyama+Y%22">Koyama Y</searchLink>; Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Tokyo, Japan.; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Abe+M%22">Abe M</searchLink>; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Maruyama+R%22">Maruyama R</searchLink>; Division of Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Division of Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Daitoku+H%22">Daitoku H</searchLink>; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Fukamizu+A%22">Fukamizu A</searchLink>; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Takano+A%22">Takano A</searchLink>; Research Platform Office, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Medical Oncology and Cancer Center, and Center for Advanced Medicine Against Cancer, Shiga University of Medical Science, Otsu, Japan.<br /><searchLink fieldCode="AU" term="%22Miyagi+Y%22">Miyagi Y</searchLink>; Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Yokose+T%22">Yokose T</searchLink>; Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Yamashita+T%22">Yamashita T</searchLink>; Department of Breast Surgery and Oncology, Kanagawa Cancer Center, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Sugahara+K%22">Sugahara K</searchLink>; Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Seimiya+H%22">Seimiya H</searchLink>; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Daigo+Y%22">Daigo Y</searchLink>; Research Platform Office, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Medical Oncology and Cancer Center, and Center for Advanced Medicine Against Cancer, Shiga University of Medical Science, Otsu, Japan.<br /><searchLink fieldCode="AU" term="%22Katakura+A%22">Katakura A</searchLink>; Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Orimo+A%22">Orimo A</searchLink>; Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Faculty of Health Sciences, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
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              Text: 2026 Jul
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