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Quantification of amyotrophic lateral sclerosis (ALS) disease accumulation with T1-weighted high-resolution magnetic resonance imaging: validation in an independent cohort.

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Title: Quantification of amyotrophic lateral sclerosis (ALS) disease accumulation with T1-weighted high-resolution magnetic resonance imaging: validation in an independent cohort.
Authors: Gremmler PA; Department of Neurology, Jena University Hospital, Jena, Germany., von der Gablentz J; Precision Neurology of Neuromuscular and Motor Neuron Diseases, University of Lübeck, Lübeck, Germany., Meyer J; Precision Neurology of Neuromuscular and Motor Neuron Diseases, University of Lübeck, Lübeck, Germany., Ilse B; Department of Neurology, Jena University Hospital, Jena, Germany., Farahi Ghasraboonasr B; Precision Neurology of Neuromuscular and Motor Neuron Diseases, University of Lübeck, Lübeck, Germany., Dalbert S; Precision Neurology of Neuromuscular and Motor Neuron Diseases, University of Lübeck, Lübeck, Germany., Buchholz IJ; Precision Neurology of Neuromuscular and Motor Neuron Diseases, University of Lübeck, Lübeck, Germany., Grosskreutz J; Department of Neurology, Jena University Hospital, Jena, Germany.; Precision Neurology of Neuromuscular and Motor Neuron Diseases, University of Lübeck, Lübeck, Germany.; Cluster for Precision Medicine in Inflammation, Universities of Kiel and Lübeck, Kiel, Germany., Steinbach R; Department of Neurology, Jena University Hospital, Jena, Germany. Robert.Steinbach@med.uni-jena.de.; MVZ Neurologie, MVZ Zentralklinik Bad Berka, Weimar, Germany. Robert.Steinbach@med.uni-jena.de.
Source: Journal of neurology [J Neurol] 2026 Jun 29; Vol. 273 (7). Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Quantification of amyotrophic lateral sclerosis (ALS) disease accumulation with T1-weighted high-resolution magnetic resonance imaging: validation in an independent cohort.
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  Data: <searchLink fieldCode="AU" term="%22Gremmler+PA%22">Gremmler PA</searchLink>; Department of Neurology, Jena University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22von+der+Gablentz+J%22">von der Gablentz J</searchLink>; Precision Neurology of Neuromuscular and Motor Neuron Diseases, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Meyer+J%22">Meyer J</searchLink>; Precision Neurology of Neuromuscular and Motor Neuron Diseases, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Ilse+B%22">Ilse B</searchLink>; Department of Neurology, Jena University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Farahi+Ghasraboonasr+B%22">Farahi Ghasraboonasr B</searchLink>; Precision Neurology of Neuromuscular and Motor Neuron Diseases, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Dalbert+S%22">Dalbert S</searchLink>; Precision Neurology of Neuromuscular and Motor Neuron Diseases, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Buchholz+IJ%22">Buchholz IJ</searchLink>; Precision Neurology of Neuromuscular and Motor Neuron Diseases, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Grosskreutz+J%22">Grosskreutz J</searchLink>; Department of Neurology, Jena University Hospital, Jena, Germany.; Precision Neurology of Neuromuscular and Motor Neuron Diseases, University of Lübeck, Lübeck, Germany.; Cluster for Precision Medicine in Inflammation, Universities of Kiel and Lübeck, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Steinbach+R%22">Steinbach R</searchLink>; Department of Neurology, Jena University Hospital, Jena, Germany. Robert.Steinbach@med.uni-jena.de.; MVZ Neurologie, MVZ Zentralklinik Bad Berka, Weimar, Germany. Robert.Steinbach@med.uni-jena.de.
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  Data: <searchLink fieldCode="JN" term="%220423161%22">Journal of neurology</searchLink> [J Neurol] 2026 Jun 29; Vol. 273 (7). <i>Date of Electronic Publication: </i>2026 Jun 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0423161 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1459 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203405354%22">03405354 </searchLink><i>NLM ISO Abbreviation: </i>J Neurol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00415-026-13937-4
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        Text: English
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      – TitleFull: Quantification of amyotrophic lateral sclerosis (ALS) disease accumulation with T1-weighted high-resolution magnetic resonance imaging: validation in an independent cohort.
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              Text: 2026 Jun 29
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