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Alpha-2-macroglobulin attenuates glucocorticoid-induced osteonecrosis of the femoral head by enhancing osteogenesis and antioxidant defense via the Akt/Nrf2 signaling pathway.

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Title: Alpha-2-macroglobulin attenuates glucocorticoid-induced osteonecrosis of the femoral head by enhancing osteogenesis and antioxidant defense via the Akt/Nrf2 signaling pathway.
Authors: He Q; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. fzszyy2023001@fjtcm.edu.cn., Zheng X; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China., Huang B; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China., Xie X; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China., Lin M; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China., Lin P; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China., Chen H; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China., Li J; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
Source: Journal of molecular histology [J Mol Histol] 2026 Jun 29; Vol. 57 (4). Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article
Journal Info: Publisher: Springer Netherlands Country of Publication: Netherlands NLM ID: 101193653 Publication Model: Electronic Cited Medium: Internet ISSN: 1567-2387 (Electronic) Linking ISSN: 15672379 NLM ISO Abbreviation: J Mol Histol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Alpha-2-macroglobulin attenuates glucocorticoid-induced osteonecrosis of the femoral head by enhancing osteogenesis and antioxidant defense via the Akt/Nrf2 signaling pathway.
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  Data: <searchLink fieldCode="AU" term="%22He+Q%22">He Q</searchLink>; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. fzszyy2023001@fjtcm.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zheng+X%22">Zheng X</searchLink>; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Huang+B%22">Huang B</searchLink>; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Xie+X%22">Xie X</searchLink>; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Lin+M%22">Lin M</searchLink>; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Lin+P%22">Lin P</searchLink>; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Bone Joint and Sports Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
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  Data: <searchLink fieldCode="JN" term="%22101193653%22">Journal of molecular histology</searchLink> [J Mol Histol] 2026 Jun 29; Vol. 57 (4). <i>Date of Electronic Publication: </i>2026 Jun 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Netherlands%22">Springer Netherlands </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101193653 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1567-2387 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215672379%22">15672379 </searchLink><i>NLM ISO Abbreviation: </i>J Mol Histol <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1007/s10735-026-10861-9
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      – Code: eng
        Text: English
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      – TitleFull: Alpha-2-macroglobulin attenuates glucocorticoid-induced osteonecrosis of the femoral head by enhancing osteogenesis and antioxidant defense via the Akt/Nrf2 signaling pathway.
        Type: main
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            – D: 29
              M: 06
              Text: 2026 Jun 29
              Type: published
              Y: 2026
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              Value: 57
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