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Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation.

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Title: Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation.
Authors: Lee CZW; Innovations in Food and Chemical Safety Programme (IFCS), A*STAR, Singapore, Singapore.; Singapore Immunology Network, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Tasnim F; Innovations in Food and Chemical Safety Programme (IFCS), A*STAR, Singapore, Singapore.; Institute of Bioengineering and Bioimaging, Singapore, Singapore., Huang X; Innovations in Food and Chemical Safety Programme (IFCS), A*STAR, Singapore, Singapore.; Institute of Bioengineering and Bioimaging, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Sethi R; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Song Y; Institute of Bioengineering and Bioimaging, Singapore, Singapore., Kozaki T; Singapore Immunology Network, Singapore, Singapore., De Schepper S; Singapore Immunology Network, Singapore, Singapore., Ang N; Singapore Immunology Network, Singapore, Singapore., Low I; Singapore Immunology Network, Singapore, Singapore., Hwang YY; Singapore Immunology Network, Singapore, Singapore., Chen J; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Yu H; Innovations in Food and Chemical Safety Programme (IFCS), A*STAR, Singapore, Singapore.; Institute of Bioengineering and Bioimaging, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Graduate School - Integrative Sciences and Engineering Programme (ISEP), Singapore, Singapore.; Mechanobiology Institute, Singapore, Singapore.; CAMP IRG, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore., Ginhoux F; Innovations in Food and Chemical Safety Programme (IFCS), A*STAR, Singapore, Singapore.; Singapore Immunology Network, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.; Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai, China.; Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.; U1356 Next Generation Immuno-Oncology research, Université Paris-Saclay, Gustave Roussy, Villejuif, France.
Source: ELife [Elife] 2026 Jun 29; Vol. 14. Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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  Data: Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation.
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  Data: <searchLink fieldCode="AU" term="%22Lee+CZW%22">Lee CZW</searchLink>; Innovations in Food and Chemical Safety Programme (IFCS), A*STAR, Singapore, Singapore.; Singapore Immunology Network, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tasnim+F%22">Tasnim F</searchLink>; Innovations in Food and Chemical Safety Programme (IFCS), A*STAR, Singapore, Singapore.; Institute of Bioengineering and Bioimaging, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; Innovations in Food and Chemical Safety Programme (IFCS), A*STAR, Singapore, Singapore.; Institute of Bioengineering and Bioimaging, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Sethi+R%22">Sethi R</searchLink>; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; Institute of Bioengineering and Bioimaging, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Kozaki+T%22">Kozaki T</searchLink>; Singapore Immunology Network, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22De+Schepper+S%22">De Schepper S</searchLink>; Singapore Immunology Network, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ang+N%22">Ang N</searchLink>; Singapore Immunology Network, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Low+I%22">Low I</searchLink>; Singapore Immunology Network, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Hwang+YY%22">Hwang YY</searchLink>; Singapore Immunology Network, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Innovations in Food and Chemical Safety Programme (IFCS), A*STAR, Singapore, Singapore.; Institute of Bioengineering and Bioimaging, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Graduate School - Integrative Sciences and Engineering Programme (ISEP), Singapore, Singapore.; Mechanobiology Institute, Singapore, Singapore.; CAMP IRG, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ginhoux+F%22">Ginhoux F</searchLink>; Innovations in Food and Chemical Safety Programme (IFCS), A*STAR, Singapore, Singapore.; Singapore Immunology Network, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.; Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai, China.; Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.; U1356 Next Generation Immuno-Oncology research, Université Paris-Saclay, Gustave Roussy, Villejuif, France.
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              Text: 2026 Jun 29
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