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In-situ cascade assembled peptide-drug conjugate for the treatment of bladder cancer by enhancing membrane-entry and lysosome destabilization.

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Title: In-situ cascade assembled peptide-drug conjugate for the treatment of bladder cancer by enhancing membrane-entry and lysosome destabilization.
Authors: Zhang P; Department of PET-CT/MRI, NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University Cancer Hospital, Harbin, 150001, China; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, 150001, China., Wu JC; Department of PET-CT/MRI, NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University Cancer Hospital, Harbin, 150001, China; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, 150001, China., Wang H; Faculty of Materials Science, Shenzhen MSU-BIT University, Shenzhen, 518115, China. Electronic address: wanghr@smbu.edu.cn., You HH; Department of PET-CT/MRI, NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University Cancer Hospital, Harbin, 150001, China; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, 150001, China., Wang DX; Department of PET-CT/MRI, 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China., Jin JY; Department of PET-CT/MRI, 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China., Duan HZ; Department of PET-CT/MRI, NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University Cancer Hospital, Harbin, 150001, China., Li MS; Department of PET-CT/MRI, NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University Cancer Hospital, Harbin, 150001, China., Li P; Department of PET-CT/MRI, 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China., Wang K; Department of PET-CT/MRI, NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University Cancer Hospital, Harbin, 150001, China., Tong ZC; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, 150001, China., Guo PY; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, 150001, China., Wang Z; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, 150001, China. Electronic address: wangziqi@hrbmu.edu.cn., Zhao YB; Department of Urology, 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. Electronic address: zhaoyubo@hrbmu.edu.cn., Tang BZ; Guangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering, Chinese University of Hong Kong (Shenzhen), Longgang, Shenzhen, Guangdong, 518172, China. Electronic address: tangbenz@cuhk.edu.cn., Hou DY; Department of PET-CT/MRI, NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University Cancer Hospital, Harbin, 150001, China. Electronic address: houdayong@hrbmu.edu.cn.
Source: Biomaterials [Biomaterials] 2026 Jun 27; Vol. 335, pp. 124405. Date of Electronic Publication: 2026 Jun 27.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: In-situ cascade assembled peptide-drug conjugate for the treatment of bladder cancer by enhancing membrane-entry and lysosome destabilization.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; Department of PET-CT/MRI, NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University Cancer Hospital, Harbin, 150001, China; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, 150001, China.<br /><searchLink fieldCode="AU" term="%22Wu+JC%22">Wu JC</searchLink>; Department of PET-CT/MRI, NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University Cancer Hospital, Harbin, 150001, China; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, 150001, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Faculty of Materials Science, Shenzhen MSU-BIT University, Shenzhen, 518115, China. Electronic address: wanghr@smbu.edu.cn.<br /><searchLink fieldCode="AU" term="%22You+HH%22">You HH</searchLink>; Department of PET-CT/MRI, NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University Cancer Hospital, Harbin, 150001, China; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, 150001, China.<br /><searchLink fieldCode="AU" term="%22Wang+DX%22">Wang DX</searchLink>; Department of PET-CT/MRI, 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.<br /><searchLink fieldCode="AU" term="%22Jin+JY%22">Jin JY</searchLink>; Department of PET-CT/MRI, 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.<br /><searchLink fieldCode="AU" term="%22Duan+HZ%22">Duan HZ</searchLink>; Department of PET-CT/MRI, NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University Cancer Hospital, Harbin, 150001, China.<br /><searchLink fieldCode="AU" term="%22Li+MS%22">Li MS</searchLink>; Department of PET-CT/MRI, NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University Cancer Hospital, Harbin, 150001, China.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Department of PET-CT/MRI, 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.<br /><searchLink fieldCode="AU" term="%22Wang+K%22">Wang K</searchLink>; Department of PET-CT/MRI, NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University Cancer Hospital, Harbin, 150001, China.<br /><searchLink fieldCode="AU" term="%22Tong+ZC%22">Tong ZC</searchLink>; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, 150001, China.<br /><searchLink fieldCode="AU" term="%22Guo+PY%22">Guo PY</searchLink>; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, 150001, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Urology, Harbin Medical University Cancer Hospital, Harbin, 150001, China. Electronic address: wangziqi@hrbmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhao+YB%22">Zhao YB</searchLink>; Department of Urology, 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. Electronic address: zhaoyubo@hrbmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Tang+BZ%22">Tang BZ</searchLink>; Guangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering, Chinese University of Hong Kong (Shenzhen), Longgang, Shenzhen, Guangdong, 518172, China. Electronic address: tangbenz@cuhk.edu.cn.<br /><searchLink fieldCode="AU" term="%22Hou+DY%22">Hou DY</searchLink>; Department of PET-CT/MRI, NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University Cancer Hospital, Harbin, 150001, China. Electronic address: houdayong@hrbmu.edu.cn.
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        Value: 10.1016/j.biomaterials.2026.124405
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        Text: English
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      – TitleFull: In-situ cascade assembled peptide-drug conjugate for the treatment of bladder cancer by enhancing membrane-entry and lysosome destabilization.
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