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Dose escalation with intraoperative radiotherapy in newly diagnosed glioblastoma (INTRAGO-II): an open-label, multicentre, randomised, controlled, phase 3 trial.

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Title: Dose escalation with intraoperative radiotherapy in newly diagnosed glioblastoma (INTRAGO-II): an open-label, multicentre, randomised, controlled, phase 3 trial.
Authors: Giordano FA; Department of Radiation Oncology, Medical Faculty Mannheim, University Medicine Mannheim, Heidelberg University, Mannheim, Germany; DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany; Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty, Heidelberg University, Mannheim, Germany. Electronic address: frank.giordano@umm.de., Ganslandt O; Department of Neurosurgery, Medical Center Stuttgart, Stuttgart, Germany., Münter MW; Department of Radiation Oncology, Medical Center Stuttgart, Stuttgart, Germany., Combs SE; Department of Radiation Oncology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany; Institute of Radiation Medicine, Helmholtz Zentrum München, Neuherberg, Germany; Deutsches Konsortium für Translationale Krebsforschung, Partner Site Munich, Munich, Germany., Diehl C; Department of Radiation Oncology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany; Institute of Radiation Medicine, Helmholtz Zentrum München, Neuherberg, Germany; Deutsches Konsortium für Translationale Krebsforschung, Partner Site Munich, Munich, Germany., Meyer B; Department of Neurosurgery, Technical University of Munich, Munich, Germany., Herrlinger U; Department of Neurooncology, Center for Neurology and Integrated Oncology, University Hospital Bonn, Bonn, Germany., Schneider M; Department of Neurosurgery, University Hospital Bonn, Bonn, Germany., Kahl KH; Department of Radiation Oncology, University Medical Center Augsburg, Augsburg, Germany., Shiban E; Department of Neurosurgery, Medical University Lausitz-Carl Thiem, Cottbus, Germany., Goenka A; Department of Radiation Medicine, Northwell, Zucker School of Medicine at Hofstra Northwell, Lake Success, New York, NY, USA., Schulder M; Department of Neurosurgery, Northwell, Zucker School of Medicine at Hofstra Northwell, Lake Success, New York, NY, USA., Lucas A; Department of Radiation Oncology, Institut Català d'Oncologia, L'Hospitalet, Barcelona, Spain., Plans G; Department of Neurosurgery, Hospital Universitari de Bellvitge, L'Hospitalet, Barcelona, Spain., Brehmer S; Department of Neurosurgery, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Ruder AM; Department of Radiation Oncology, Medical Faculty Mannheim, University Medicine Mannheim, Heidelberg University, Mannheim, Germany., García-Cabezas S; Department of Radiation Oncology, Reina Sofia University Hospital, Instituto Maimónides de Investigaciones Biomédicas de Córdoba, Córdoba, Spain., Solivera J; Department of Neurosurgery, Reina Sofia University Hospital, Instituto Maimónides de Investigaciones Biomédicas de Córdoba, Córdoba, Spain., Cifarelli CP; Department of Neurosurgery, West Virginia University, Morgantown, West Virginia, USA., Wenz F; Freiburg University Medical Center, University of Freiburg, Freiburg, Germany., Sarria GR; Department of Radiation Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany., Pope WB; UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Layer JP; Department of Radiation Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany; Institute of Experimental Oncology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany., Tsien CI; Department of Radiation Oncology, McGill University, Montreal, Quebec, Canada., Petrecca K; Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.
Corporate Authors: INTRAGO-II Study Group
Source: The Lancet. Oncology [Lancet Oncol] 2026 Jul; Vol. 27 (7), pp. 864-878.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Clinical Trial, Phase III
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dose escalation with intraoperative radiotherapy in newly diagnosed glioblastoma (INTRAGO-II): an open-label, multicentre, randomised, controlled, phase 3 trial.
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  Data: <searchLink fieldCode="AU" term="%22Giordano+FA%22">Giordano FA</searchLink>; Department of Radiation Oncology, Medical Faculty Mannheim, University Medicine Mannheim, Heidelberg University, Mannheim, Germany; DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany; Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty, Heidelberg University, Mannheim, Germany. Electronic address: frank.giordano@umm.de.<br /><searchLink fieldCode="AU" term="%22Ganslandt+O%22">Ganslandt O</searchLink>; Department of Neurosurgery, Medical Center Stuttgart, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Münter+MW%22">Münter MW</searchLink>; Department of Radiation Oncology, Medical Center Stuttgart, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Combs+SE%22">Combs SE</searchLink>; Department of Radiation Oncology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany; Institute of Radiation Medicine, Helmholtz Zentrum München, Neuherberg, Germany; Deutsches Konsortium für Translationale Krebsforschung, Partner Site Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Diehl+C%22">Diehl C</searchLink>; Department of Radiation Oncology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany; Institute of Radiation Medicine, Helmholtz Zentrum München, Neuherberg, Germany; Deutsches Konsortium für Translationale Krebsforschung, Partner Site Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Meyer+B%22">Meyer B</searchLink>; Department of Neurosurgery, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Herrlinger+U%22">Herrlinger U</searchLink>; Department of Neurooncology, Center for Neurology and Integrated Oncology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+M%22">Schneider M</searchLink>; Department of Neurosurgery, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kahl+KH%22">Kahl KH</searchLink>; Department of Radiation Oncology, University Medical Center Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Shiban+E%22">Shiban E</searchLink>; Department of Neurosurgery, Medical University Lausitz-Carl Thiem, Cottbus, Germany.<br /><searchLink fieldCode="AU" term="%22Goenka+A%22">Goenka A</searchLink>; Department of Radiation Medicine, Northwell, Zucker School of Medicine at Hofstra Northwell, Lake Success, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Schulder+M%22">Schulder M</searchLink>; Department of Neurosurgery, Northwell, Zucker School of Medicine at Hofstra Northwell, Lake Success, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lucas+A%22">Lucas A</searchLink>; Department of Radiation Oncology, Institut Català d'Oncologia, L'Hospitalet, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Plans+G%22">Plans G</searchLink>; Department of Neurosurgery, Hospital Universitari de Bellvitge, L'Hospitalet, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Brehmer+S%22">Brehmer S</searchLink>; Department of Neurosurgery, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Ruder+AM%22">Ruder AM</searchLink>; Department of Radiation Oncology, Medical Faculty Mannheim, University Medicine Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22García-Cabezas+S%22">García-Cabezas S</searchLink>; Department of Radiation Oncology, Reina Sofia University Hospital, Instituto Maimónides de Investigaciones Biomédicas de Córdoba, Córdoba, Spain.<br /><searchLink fieldCode="AU" term="%22Solivera+J%22">Solivera J</searchLink>; Department of Neurosurgery, Reina Sofia University Hospital, Instituto Maimónides de Investigaciones Biomédicas de Córdoba, Córdoba, Spain.<br /><searchLink fieldCode="AU" term="%22Cifarelli+CP%22">Cifarelli CP</searchLink>; Department of Neurosurgery, West Virginia University, Morgantown, West Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Wenz+F%22">Wenz F</searchLink>; Freiburg University Medical Center, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sarria+GR%22">Sarria GR</searchLink>; Department of Radiation Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Pope+WB%22">Pope WB</searchLink>; UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Layer+JP%22">Layer JP</searchLink>; Department of Radiation Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany; Institute of Experimental Oncology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Tsien+CI%22">Tsien CI</searchLink>; Department of Radiation Oncology, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Petrecca+K%22">Petrecca K</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.
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  Data: <searchLink fieldCode="CA" term="%22INTRAGO-II+Study+Group%22">INTRAGO-II Study Group</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22100957246%22">The Lancet. Oncology</searchLink> [Lancet Oncol] 2026 Jul; Vol. 27 (7), pp. 864-878.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lancet+Pub%2E+Group%22">Lancet Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100957246 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-5488 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214702045%22">14702045 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Oncol <i>Subsets: </i>MEDLINE
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