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Interleukin-6 stimulates platelet 12-lipoxygenase to drive coagulation in inflammatory arthritis.

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Title: Interleukin-6 stimulates platelet 12-lipoxygenase to drive coagulation in inflammatory arthritis.
Authors: Costa DO; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK. Electronic address: costad2@cardiff.ac.uk., Hughes STO; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Jenkins RH; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Figueras AC; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Protty MB; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Tyrrell VJ; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Hajeyah AA; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Jones GW; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom., Burston JJ; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Morgan B; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Monaco F; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Hill D; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom., Morrin AS; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Guy C; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Bacon A; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Giera M; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands., Toes REM; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Jenkins PV; Haematology Department, Cardiff and Vale University Health Board, Cardiff, United Kingdom., Collins PW; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Choy E; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Jones SA; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., O'Donnell VB; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK. Electronic address: o-donnellvb@cardiff.ac.uk.
Source: Journal of lipid research [J Lipid Res] 2026 Jun 29; Vol. 67 (8), pp. 101093. Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-7262 (Electronic) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Interleukin-6 stimulates platelet 12-lipoxygenase to drive coagulation in inflammatory arthritis.
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  Data: <searchLink fieldCode="AU" term="%22Costa+DO%22">Costa DO</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK. Electronic address: costad2@cardiff.ac.uk.<br /><searchLink fieldCode="AU" term="%22Hughes+STO%22">Hughes STO</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Jenkins+RH%22">Jenkins RH</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Figueras+AC%22">Figueras AC</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Protty+MB%22">Protty MB</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Tyrrell+VJ%22">Tyrrell VJ</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Hajeyah+AA%22">Hajeyah AA</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Jones+GW%22">Jones GW</searchLink>; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Burston+JJ%22">Burston JJ</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Morgan+B%22">Morgan B</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Monaco+F%22">Monaco F</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Hill+D%22">Hill D</searchLink>; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Morrin+AS%22">Morrin AS</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Guy+C%22">Guy C</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Bacon+A%22">Bacon A</searchLink>; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Giera+M%22">Giera M</searchLink>; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Toes+REM%22">Toes REM</searchLink>; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Jenkins+PV%22">Jenkins PV</searchLink>; Haematology Department, Cardiff and Vale University Health Board, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Collins+PW%22">Collins PW</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Choy+E%22">Choy E</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Jones+SA%22">Jones SA</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22O'Donnell+VB%22">O'Donnell VB</searchLink>; Systems Immunity Research Institute, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK. Electronic address: o-donnellvb@cardiff.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%220376606%22">Journal of lipid research</searchLink> [J Lipid Res] 2026 Jun 29; Vol. 67 (8), pp. 101093. <i>Date of Electronic Publication: </i>2026 Jun 29.
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